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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Clasp2  -  CLIP associating protein 2

Mus musculus

Synonyms: 1500004F14Rik, 8030404L10Rik, C77448, CLASP2, CLASP2alpha, ...
 
 
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High impact information on Clasp2

  • Antibody injections suggest that CLASP2 is required for the orientation of stabilized microtubules toward the leading edge [1].
  • We find that ACF7 regulates cortical CLASP localization in HeLa cells, indicating it acts upstream of CLASP2 [2].
  • Our results suggest that the regional immobilization of CLASP2 allows MT stabilization and promotes directionally persistent motility in fibroblasts [2].

References

  1. Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. Akhmanova, A., Hoogenraad, C.C., Drabek, K., Stepanova, T., Dortland, B., Verkerk, T., Vermeulen, W., Burgering, B.M., De Zeeuw, C.I., Grosveld, F., Galjart, N. Cell (2001) [Pubmed]
  2. Role of CLASP2 in Microtubule Stabilization and the Regulation of Persistent Motility. Drabek, K., van Ham, M., Stepanova, T., Draegestein, K., van Horssen, R., Sayas, C.L., Akhmanova, A., Ten Hagen, T., Smits, R., Fodde, R., Grosveld, F., Galjart, N. Curr. Biol. (2006) [Pubmed]
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