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Gene Review

CLASP2  -  cytoplasmic linker associated protein 2

Homo sapiens

Synonyms: CLIP-associating protein 2, Cytoplasmic linker-associated protein 2, KIAA0627, Protein Orbit homolog 2, hOrbit2
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High impact information on CLASP2

  • Antibody injections suggest that CLASP2 is required for the orientation of stabilized microtubules toward the leading edge [1].
  • CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex [2].
  • We find that ACF7 regulates cortical CLASP localization in HeLa cells, indicating it acts upstream of CLASP2 [3].
  • Our results suggest that the regional immobilization of CLASP2 allows MT stabilization and promotes directionally persistent motility in fibroblasts [3].
  • We show that the association of CLASP2 with the kinetochores relies on its C-terminal domain, but is independent of microtubules or association with CLIP-170 [4].


  1. Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. Akhmanova, A., Hoogenraad, C.C., Drabek, K., Stepanova, T., Dortland, B., Verkerk, T., Vermeulen, W., Burgering, B.M., De Zeeuw, C.I., Grosveld, F., Galjart, N. Cell (2001) [Pubmed]
  2. CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex. Mimori-Kiyosue, Y., Grigoriev, I., Lansbergen, G., Sasaki, H., Matsui, C., Severin, F., Galjart, N., Grosveld, F., Vorobjev, I., Tsukita, S., Akhmanova, A. J. Cell Biol. (2005) [Pubmed]
  3. Role of CLASP2 in Microtubule Stabilization and the Regulation of Persistent Motility. Drabek, K., van Ham, M., Stepanova, T., Draegestein, K., van Horssen, R., Sayas, C.L., Akhmanova, A., Ten Hagen, T., Smits, R., Fodde, R., Grosveld, F., Galjart, N. Curr. Biol. (2006) [Pubmed]
  4. Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment. Mimori-Kiyosue, Y., Grigoriev, I., Sasaki, H., Matsui, C., Akhmanova, A., Tsukita, S., Vorobjev, I. Genes Cells (2006) [Pubmed]
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