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Msi2  -  musashi RNA-binding protein 2

Mus musculus

Synonyms: 1700105C15Rik, AI451722, AI563628, AW489193, Msi2h, ...
 
 
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High impact information on Msi2

  • Whole mount in situ hybridization against two genes of previously unknown embryonic expression, Lrrn1 and Musashi2, confirmed the selectivity of this screen for early neuroectodermal markers [1].
  • In mammals, two members of this family, Musashi1 (Msi1) and Musashi2 (Msi2), are strongly coexpressed in neural precursor cells, including CNS stem cells [2].
  • In the postnatal and adult CNS, this concurrent expression of Msi2 and Msi1 was seen in cells of the astrocyte lineage, including ependymal cells, a possible source for postnatal CNS stem cells [3].
 

Anatomical context of Msi2

  • In the early anagen phase, Msi-1 and Msi-2 were expressed in the bulge and secondary germ cells and subsequently in inner root sheath (IRS) cells, especially the middle IRS cells, during the late anagen phase [4].

References

  1. Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice. Aubert, J., Stavridis, M.P., Tweedie, S., O'Reilly, M., Vierlinger, K., Li, M., Ghazal, P., Pratt, T., Mason, J.O., Roy, D., Smith, A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation. Sakakibara, S., Nakamura, Y., Yoshida, T., Shibata, S., Koike, M., Takano, H., Ueda, S., Uchiyama, Y., Noda, T., Okano, H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Rna-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS. Sakakibara, S., Nakamura, Y., Satoh, H., Okano, H. J. Neurosci. (2001) [Pubmed]
  4. Expression of RNA-binding protein Musashi in hair follicle development and hair cycle progression. Sugiyama-Nakagiri, Y., Akiyama, M., Shibata, S., Okano, H., Shimizu, H. Am. J. Pathol. (2006) [Pubmed]
 
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