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Gene Review

PCGF2  -  polycomb group ring finger 2

Homo sapiens

Synonyms: DNA-binding protein Mel-18, MEL-18, MEL18, Polycomb group RING finger protein 2, RING finger protein 110, ...
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High impact information on PCGF2

  • Up- or downregulation of MEL18 was paralleled by loss or gain of activated NFkappaB, which suggests that NFkappaB may regulate expression of this protein [1].
  • Rnf110 and Phc2 are shown to be components of mammalian PcG multimeric complexes in HeLa cells [2].
  • Rnf110 and Phc2 mutations impair development of PP anlagen by affecting proliferation of lymphoid lineage cells populated in PP anlagen in gene-dosage dependent manner [2].
  • Furthermore, at least three PcG genes, Bmi1, Rae28, and Mel18, appear to regulate self-renewal of specific stem cell types suggesting a link between the maintenance of cellular homeostasis and tumorigenesis [3].


  1. Abnormal PcG protein expression in Hodgkin's lymphoma. Relation with E2F6 and NFkappaB transcription factors. Sánchez-Beato, M., Sánchez, E., García, J.F., Pérez-Rosado, A., Montoya, M.C., Fraga, M., Artiga, M.J., Navarrete, M., Abraira, V., Morente, M., Esteller, M., Koseki, H., Vidal, M., Piris, M.A. J. Pathol. (2004) [Pubmed]
  2. Mammalian Polycomb complexes are required for Peyer's patch development by regulating lymphoid cell proliferation. Sato, T., Endoh, M., Yoshida, H., Yasuo, S., Katsuno, T., Saito, Y., Isono, K., Koseki, H. Gene (2006) [Pubmed]
  3. Role of polycomb group proteins in stem cell self-renewal and cancer. Gil, J., Bernard, D., Peters, G. DNA Cell Biol. (2005) [Pubmed]
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