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Gene Review

ZNF214  -  zinc finger protein 214

Homo sapiens

Synonyms: BAZ-1, BAZ1, BWSCR2-associated zinc finger protein 1, Zinc finger protein 214
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Disease relevance of ZNF214

  • Cryptorchidism and reduced fecundity are symptoms in male Beckwith-Wiedemann patients and the ZNF214 and ZNF215 genes, localized on chromosomal region 11p15, are associated with this syndrome [1].

High impact information on ZNF214

  • Parts of the 3' end of these splice forms are transcribed from the antisense strand of a second zinc-finger gene, ZNF214 [2].
  • Mutation analysis in ZNF214 and ZNF215 revealed five new variants in the patients that were not present in the controls [1].

Biological context of ZNF214


  1. Chromosomal region 11p15 is associated with male factor subfertility. Gianotten, J., van der Veen, F., Alders, M., Leschot, N.J., Tanck, M.W., Land, J.A., Kremer, J.A., Hoefsloot, L.H., Mannens, M.M., Lombardi, M.P., Hoffer, M.J. Mol. Hum. Reprod. (2003) [Pubmed]
  2. Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome. Alders, M., Ryan, A., Hodges, M., Bliek, J., Feinberg, A.P., Privitera, O., Westerveld, A., Little, P.F., Mannens, M. Am. J. Hum. Genet. (2000) [Pubmed]
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