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Gene Review:

ZNF214 - zinc finger protein 214

Homo sapiens

Synonyms: BAZ-1, BAZ1, BWSCR2-associated zinc finger protein 1, Zinc finger protein 214

Gianotten, J. et al., Alders, M. et al.

Gianotten, van der Veen, Alders, Leschot, Tanck, Land, Kremer, Hoefsloot, Mannens, Lombardi, Hoffer,

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Disease relevance of ZNF214

Cryptorchidism and reduced fecundity are symptoms in male Beckwith-Wiedemann patients and the ZNF214 and ZNF215 genes, localized on chromosomal region 11p15, are associated with this syndrome [1].

High impact information on ZNF214

Parts of the 3' end of these splice forms are transcribed from the antisense strand of a second zinc-finger gene, ZNF214 [2].
Mutation analysis in ZNF214 and ZNF215 revealed five new variants in the patients that were not present in the controls [1].

Biological context of ZNF214

Male partners of subfertile couples with idiopathic azoo- or severe oligozoospermia, male partners with azoo- or severe oligozoospermia and cryptorchidism in their medical history and men with normozoospermia were screened for nine single nucleotide polymorphisms in the ZNF214 and ZNF215 genes [1].
We hypothesized that the ZNF214 and ZNF215 genes, which are predominantly expressed in the testis, could be involved in male factor subfertility in patients with idiopathic impaired spermatogenesis or in patients with impaired spermatogenesis due to cryptorchidism [1].

References

Chromosomal region 11p15 is associated with male factor subfertility. Gianotten, J., van der Veen, F., Alders, M., Leschot, N.J., Tanck, M.W., Land, J.A., Kremer, J.A., Hoefsloot, L.H., Mannens, M.M., Lombardi, M.P., Hoffer, M.J. Mol. Hum. Reprod. (2003) [Pubmed]
Disruption of a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome. Alders, M., Ryan, A., Hodges, M., Bliek, J., Feinberg, A.P., Privitera, O., Westerveld, A., Little, P.F., Mannens, M. Am. J. Hum. Genet. (2000) [Pubmed]

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