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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Fertility


Psychiatry related information on Fertility


High impact information on Fertility


Chemical compound and disease context of Fertility


Biological context of Fertility

  • In addition to being the first identified egg components of the nematode fertilization machinery, the egg-1 and egg-2 gene duplication could be vital with regards to maximizing C. elegans fecundity and understanding the evolutionary differentiation of molecular function and speciation [17].
  • The k = 0.50 and the high fecundity of SDi/SDj combinations indicated that in these males the SD phenomenon is partially suppressed, the SD chromosomes being insensitive to each other, thus implying that particular Rsp alleles are sensitive to given Sd alleles [18].
  • Chronological changes in fertility, fecundity and steroid hormone secretion during consecutive pregnancies in aging rats [19].
  • There was no evidence that female fecundity was influenced by their Pgdh genotype [20].
  • Ovulation in ewes selected for fecundity: effect of synthetic Gn-RH injected on the day of oestrus [21].

Anatomical context of Fertility

  • Although PAFR(-/-) infected mice showed a delay in elimination of adult worms, worms established in the small intestine of these mice produced a significantly lower number of eggs due to a reduction in worm fecundity [22].
  • Spermatozoa from ICSI-derived azh/+ males did not show any impairment of fecundity in in vitro fertilization [23].
  • Comparison of follicle steroidogenesis from normal and polycystic ovaries in women undergoing IVF: relationship between steroid concentrations, follicle size, oocyte quality and fecundability [24].
  • OBJECTIVE: To assess whether a relationship exists between follicular fluid (FF) angiotensin II (AII) concentration and pregnancy outcome or earlier fecundity parameters and whether correlations exist among FF AII concentrations and P, E2, T, androstenedione (A), or various ratios of these [25].
  • Granulosa cells from follicles of different sizes from Booroola x Merino ewes which were homozygous (FF), heterozygous (F+) or non-carriers(++) of a fecundity gene were obtained 0-48 h after cloprostenol injection on Day 10 of the oestrous cycle [26].

Associations of Fertility with chemical compounds

  • The fecundability ratio adjusted for known risk factors for time to conceive was 1.03 (95% confidence interval 0.92-1.16) between those who consumed more than 7000 mg caffeine per month and those who consumed 500 mg or less per month [27].
  • Whether this will cause reduced fecundity, and how these effects can be extrapolated to the general population exposed to background levels of PCBs and dioxin-like chemicals, warrants further investigation [28].
  • However, seed-addition experiments in a southern California grassland revealed that native perennial species, which had lower requirements for deep soil water, soil nitrate, and light, were strong competitors, and they markedly depressed the abundance and fecundity of exotic annuals after overcoming recruitment limitations [29].
  • Gonadal protection and fecundity rates in cyclophosphamide-treated rats [30].
  • Lupron given every 12 h had a similar effect on fertility, but failed to protect fecundity (P less than 0.001) [30].

Gene context of Fertility

  • However, Indy mutants on a decreased-calorie diet have reduced fecundity, suggesting that a tradeoff between longevity and this aspect of performance is conditional, i.e., the tradeoff can occur in a stressful environment while being absent in a more favorable environment [31].
  • The differential fertility of clk-1 mutant nematodes fed Q isoforms may result from changes in Q localization, altered recognition by Q-binding proteins, and/or potential defects in mitochondrial function resulting from the mutant CLK-1 polypeptide itself [32].
  • EcR mutant females raised at permissive temperature and then shifted to restrictive temperature exhibit severe reductions in fecundity [33].
  • Regarding unc-60 itself, we compared the effect of ten alleles (including five isolated during this study) on hermaphrodite mobility and fecundity [34].
  • In addition, as predicted above, females that did or did not receive Acp26Aa did not differ in survival, lifetime fecundity or lifetime progeny, indicating that Acp26Aa transfer does not represent a significant energetic cost for females and does not contribute to the survival cost of mating [35].

Analytical, diagnostic and therapeutic context of Fertility


  1. Egg laying is delayed but worm fecundity is normal in SCID mice infected with Schistosoma japonicum and S. mansoni with or without recombinant tumor necrosis factor alpha treatment. Cheever, A.W., Poindexter, R.W., Wynn, T.A. Infect. Immun. (1999) [Pubmed]
  2. A randomized, controlled trial of clomiphene citrate and intrauterine insemination in couples with unexplained infertility or surgically corrected endometriosis. Deaton, J.L., Gibson, M., Blackmer, K.M., Nakajima, S.T., Badger, G.J., Brumsted, J.R. Fertil. Steril. (1990) [Pubmed]
  3. Correlation of fecundability and serum estradiol after danazol treatment in patients with advanced endometriosis. Chen, F.P., Chu, K.K., Soong, Y.K. Fertil. Steril. (1996) [Pubmed]
  4. Is tumour necrosis factor alpha the molecular basis of concomitant immunity in schistosomiasis? Hagan, P., Garside, P., Kusel, J.R. Parasite Immunol. (1993) [Pubmed]
  5. Paternal alcohol exposure affects sperm cytosine methyltransferase messenger RNA levels. Bielawski, D.M., Zaher, F.M., Svinarich, D.M., Abel, E.L. Alcohol. Clin. Exp. Res. (2002) [Pubmed]
  6. Cigarette smoking, alcohol consumption, and caffeine intake and fecundability. Florack, E.I., Zielhuis, G.A., Rolland, R. Preventive medicine. (1994) [Pubmed]
  7. Rising CO2 levels and the fecundity of forest trees. LaDeau, S.L., Clark, J.S. Science (2001) [Pubmed]
  8. C. elegans mre-11 is required for meiotic recombination and DNA repair but is dispensable for the meiotic G(2) DNA damage checkpoint. Chin, G.M., Villeneuve, A.M. Genes Dev. (2001) [Pubmed]
  9. Short KIR haplotypes in pygmy chimpanzee (Bonobo) resemble the conserved framework of diverse human KIR haplotypes. Rajalingam, R., Hong, M., Adams, E.J., Shum, B.P., Guethlein, L.A., Parham, P. J. Exp. Med. (2001) [Pubmed]
  10. Delayed expulsion of the nematode Trichinella spiralis in mice lacking the mucosal mast cell-specific granule chymase, mouse mast cell protease-1. Knight, P.A., Wright, S.H., Lawrence, C.E., Paterson, Y.Y., Miller, H.R. J. Exp. Med. (2000) [Pubmed]
  11. Induction of primary antiphospholipid syndrome in mice by immunization with a human monoclonal anticardiolipin antibody (H-3). Bakimer, R., Fishman, P., Blank, M., Sredni, B., Djaldetti, M., Shoenfeld, Y. J. Clin. Invest. (1992) [Pubmed]
  12. Success of intrauterine insemination using cryopreserved donor sperm is related to the age of the woman and the number of preovulatory follicles. Pittrof, R.U., Shaker, A., Dean, N., Bekir, J.S., Campbell, S., Tan, S.L. J. Assist. Reprod. Genet. (1996) [Pubmed]
  13. Survival, growth and reproduction of Daphnia carinata (Crustacea: Cladocera) exposed to chronic cadmium stress at different food (Chlorella) levels. Chandini, T. Environ. Pollut. (1989) [Pubmed]
  14. The effects of cortisone on fecundity, number, and distribution of adult Trichinella spiralis and on trichinous enteritis in the host. Stewart, G.L., Kramar, G.W., Kramar, M., Charniga, L. J. Parasitol. (1982) [Pubmed]
  15. The genetics of obesity. Lessons for polycystic ovary syndrome. Legro, R.S. Ann. N. Y. Acad. Sci. (2000) [Pubmed]
  16. Evaluation of water treatment sludges toxicity using the Daphnia bioassay. Sotero-Santos, R.B., Rocha, O., Povinelli, J. Water Res. (2005) [Pubmed]
  17. The egg surface LDL receptor repeat-containing proteins EGG-1 and EGG-2 are required for fertilization in Caenorhabditis elegans. Kadandale, P., Stewart-Michaelis, A., Gordon, S., Rubin, J., Klancer, R., Schweinsberg, P., Grant, B.D., Singson, A. Curr. Biol. (2005) [Pubmed]
  18. Biological parameters and the segregation distortion (SD) phenomenon in Drosophila melanogaster. Trippa, G., Cicchetti, R., Loverre, A., Micheli, A. Genetics (1981) [Pubmed]
  19. Chronological changes in fertility, fecundity and steroid hormone secretion during consecutive pregnancies in aging rats. Matt, D.W., Lee, J., Sarver, P.L., Judd, H.L., Lu, J.K. Biol. Reprod. (1986) [Pubmed]
  20. Strong association between a single gene and fertilization efficiency of males and fecundity of their mates in the bulb mite. Konior, M., Radwan, J., Kołodziejczyk, M., Keller, L. Proc. Biol. Sci. (2006) [Pubmed]
  21. Ovulation in ewes selected for fecundity: effect of synthetic Gn-RH injected on the day of oestrus. Bindon, B.M. J. Reprod. Fertil. (1975) [Pubmed]
  22. Platelet-activating factor receptor deficiency delays elimination of adult worms but reduces fecundity in Strongyloides venezuelensis-infected mice. Negrão-Corrêa, D., Souza, D.G., Pinho, V., Barsante, M.M., Souza, A.L., Teixeira, M.M. Infect. Immun. (2004) [Pubmed]
  23. Intracytoplasmic sperm injection effects in infertile azh mutant mice. Ward, M.A. Biol. Reprod. (2005) [Pubmed]
  24. Comparison of follicle steroidogenesis from normal and polycystic ovaries in women undergoing IVF: relationship between steroid concentrations, follicle size, oocyte quality and fecundability. Teissier, M.P., Chable, H., Paulhac, S., Aubard, Y. Hum. Reprod. (2000) [Pubmed]
  25. Elevated follicular fluid angiotensin II and pregnancy outcome. Heimler, I., Rawlins, R.G., Binor, Z., Aiman, J., Raff, H., Hutz, R.J. Fertil. Steril. (1995) [Pubmed]
  26. Differences in gonadotrophin-stimulated cyclic AMP production by granulosa cells from booroola x merino ewes which were homozygous, heterozygous or non-carriers of a fecundity gene influencing their ovulation rate. Henderson, K.M., McNatty, K.P., O'Keeffe, L.E., Lun, S., Heath, D.A., Prisk, M.D. J. Reprod. Fertil. (1987) [Pubmed]
  27. Are caffeinated beverages risk factors for delayed conception? Joesoef, M.R., Beral, V., Rolfs, R.T., Aral, S.O., Cramer, D.W. Lancet (1990) [Pubmed]
  28. Semen quality after prenatal exposure to polychlorinated biphenyls and dibenzofurans. Guo, Y.L., Hsu, P.C., Hsu, C.C., Lambert, G.H. Lancet (2000) [Pubmed]
  29. Invasion, competitive dominance, and resource use by exotic and native California grassland species. Seabloom, E.W., Harpole, W.S., Reichman, O.J., Tilman, D. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  30. Gonadal protection and fecundity rates in cyclophosphamide-treated rats. Montz, F.J., Wolff, A.J., Gambone, J.C. Cancer Res. (1991) [Pubmed]
  31. Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies. Marden, J.H., Rogina, B., Montooth, K.L., Helfand, S.L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  32. Reproductive fitness and quinone content of Caenorhabditis elegans clk-1 mutants fed coenzyme Q isoforms of varying length. Jonassen, T., Davis, D.E., Larsen, P.L., Clarke, C.F. J. Biol. Chem. (2003) [Pubmed]
  33. The Drosophila ecdysone receptor (EcR) gene is required maternally for normal oogenesis. Carney, G.E., Bender, M. Genetics (2000) [Pubmed]
  34. Genetic organization of the unc-60 region in Caenorhabditis elegans. McKim, K.S., Heschl, M.F., Rosenbluth, R.E., Baillie, D.L. Genetics (1988) [Pubmed]
  35. The Acp26Aa seminal fluid protein is a modulator of early egg hatchability in Drosophila melanogaster. Chapman, T., Herndon, L.A., Heifetz, Y., Partridge, L., Wolfner, M.F. Proc. Biol. Sci. (2001) [Pubmed]
  36. Vaccination of dogs with a recombinant cysteine protease from the intestine of canine hookworms diminishes the fecundity and growth of worms. Loukas, A., Bethony, J.M., Williamson, A.L., Goud, G.N., Mendez, S., Zhan, B., Hawdon, J.M., Elena Bottazzi, M., Brindley, P.J., Hotez, P.J. J. Infect. Dis. (2004) [Pubmed]
  37. Electroejaculation and assisted reproductive technologies in the treatment of anejaculatory infertility. Ohl, D.A., Wolf, L.J., Menge, A.C., Christman, G.M., Hurd, W.W., Ansbacher, R., Smith, Y.R., Randolph, J.F. Fertil. Steril. (2001) [Pubmed]
  38. Effects of luteal phase administration of mifepristone (RU486) and prostaglandin analogue or inhibitor on endometrium in the rhesus monkey. Nayak, N.R., Ghosh, D., Sengupta, J. Hum. Reprod. (1998) [Pubmed]
  39. Effect of castration on plasma concentrations of luteinizing hormone and follicle-stimulating hormone in adult Merino rams which were homozygous carriers or non-carriers of the Booroola fecundity gene. Price, C.A., Hudson, N.L., McNatty, K.P. J. Reprod. Fertil. (1991) [Pubmed]
  40. The crucial role of granulocytes in the early host defense against Strongyloides ratti infection in mice. Watanabe, K., Noda, K., Hamano, S., Koga, M., Kishihara, K., Nomoto, K., Tada, I. Parasitol. Res. (2000) [Pubmed]
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