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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SLC30A2  -  solute carrier family 30 (zinc...

Homo sapiens

Synonyms: PP12488, Solute carrier family 30 member 2, TNZD, ZNT2, Zinc transporter 2, ...
 
 
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High impact information on SLC30A2

  • Gene knockdown of SLC30A2 in mammary epithelial cells reduced zinc secretion, illustrating the role of ZnT-2 in zinc secretion from this cell type [1].
  • Sequencing of genomic DNA detected a mis-sense mutation (Ade-->Gua) that substitutes a conserved histidine at amino acid 54 with arginine (H54R) in SLC30A2 (ZnT-2) that is present in both affected subjects and several other siblings [1].
  • ZnT-2 and ZnT-3 may function in tissue-specific vesicular zinc transport [2].
  • ZnT-2 is also an exporter and may be involved in zinc efflux or uptake into vesicles in intestine, kidney, and testis [3].

References

  1. Identification of a Mutation in SLC30A2 (ZnT-2) in Women with Low Milk Zinc Concentration That Results in Transient Neonatal Zinc Deficiency. Chowanadisai, W., L??nnerdal, B., Kelleher, S.L. J. Biol. Chem. (2006) [Pubmed]
  2. Integrative aspects of zinc transporters. Cousins, R.J., McMahon, R.J. J. Nutr. (2000) [Pubmed]
  3. Mammalian zinc transporters. McMahon, R.J., Cousins, R.J. J. Nutr. (1998) [Pubmed]
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