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Gene Review

SLC30A3  -  solute carrier family 30 (zinc...

Homo sapiens

Synonyms: Solute carrier family 30 member 3, ZNT3, Zinc transporter 3, ZnT-3
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High impact information on SLC30A3


Biological context of SLC30A3

  • Accordingly, pharmacological disruption of either AP-2- or AP-3-dependent SLMV biogenesis preferentially reduced synaptophysin or ZnT3 targeting, respectively; suggesting that these antigens were concentrated in different vesicles [2].
  • However there appears to be little chelatable (synaptic) zinc in the cerebellum, deletion of the ZnT-3 gene has no effect on motor phenotype and there is currently no evidence that zinc is released from cerebellar neurones to have physiological actions [3].
  • Over-expression of the zinc transporter 3 gene was identified as the most prominent change in gene expression due to omega-3 PUFA deficiency [4].
  • The possibility that zinc is involved in cerebellar synaptic transmission is supported by the expression of specific zinc transporters (ZnT, including the synaptic vesicle transporter ZnT-3) in the cerebellar cortex [3].

Anatomical context of SLC30A3


Associations of SLC30A3 with chemical compounds

  • Furthermore, the expression of ZnT3 mRNA was decreased by incubating LNCaP cells in medium containing hormone-stripped fetal calf serum and increased by addition of synthetic androgen R1881 to the medium, whereas the intracellular zinc levels were not affected under these conditions [8].
  • The autometallography staining resulting from the "sulfide only immersion" was not particularly impressive, but the significance of this return to an old approach became obvious when Wenzel and co-workers presented their approach in connection with introduction by the Palmiter group of zinc transporter 3 (ZnT3) [9].

Other interactions of SLC30A3

  • These findings suggest that factors such as ZnT1 and metallothioneins other than ZnT3 are associated with the low intracellular zinc content in AIDL cells [8].
  • ZnT-2 and ZnT-3 may function in tissue-specific vesicular zinc transport [10].


  1. ZnT-3, a putative transporter of zinc into synaptic vesicles. Palmiter, R.D., Cole, T.B., Quaife, C.J., Findley, S.D. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation. Salazar, G., Love, R., Werner, E., Doucette, M.M., Cheng, S., Levey, A., Faundez, V. Mol. Biol. Cell (2004) [Pubmed]
  3. A role for zinc in cerebellar synaptic transmission? Wall, M.J. Cerebellum (2005) [Pubmed]
  4. Influence of dietary omega-3 polyunsaturated fatty acid (PUFA) supply on brain gene expression. Jayasooriya, A.P., Weisinger, R.S., Weisinger, H.S., Mathai, M., Puskas, L., Kitajka, K., Chen, N., Ackland, M.L., Sinclair, A.J. Asia Pacific journal of clinical nutrition. (2004) [Pubmed]
  5. Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells. Michalczyk, A.A., Allen, J., Blomeley, R.C., Ackland, M.L. Biochem. J. (2002) [Pubmed]
  6. Survey of mRNAs encoding zinc transporters and other metal complexing proteins in pancreatic islets of rats from birth to adulthood: similar patterns in the Sprague-Dawley and Wistar BB strains. Clifford, K.S., MacDonald, M.J. Diabetes Res. Clin. Pract. (2000) [Pubmed]
  7. Metallothioneins and zinc dysregulation contribute to neurodevelopmental damage in a model of perinatal viral infection. Williams, B.L., Yaddanapudi, K., Kirk, C.M., Soman, A., Hornig, M., Lipkin, W.I. Brain Pathol. (2006) [Pubmed]
  8. Zinc and metallothionein levels and expression of zinc transporters in androgen-independent subline of LNCaP cells. Iguchi, K., Otsuka, T., Usui, S., Ishii, K., Onishi, T., Sugimura, Y., Hirano, K. J. Androl. (2004) [Pubmed]
  9. Immersion autometallography: histochemical in situ capturing of zinc ions in catalytic zinc-sulfur nanocrystals. Danscher, G., Stoltenberg, M., Bruhn, M., Søndergaard, C., Jensen, D. J. Histochem. Cytochem. (2004) [Pubmed]
  10. Integrative aspects of zinc transporters. Cousins, R.J., McMahon, R.J. J. Nutr. (2000) [Pubmed]
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