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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ERI3  -  ERI1 exoribonuclease family member 3

Homo sapiens

Synonyms: ERI1 exoribonuclease 3, FLJ22943, PINT1, PRNPIP, PRNPIP1, ...
 
 
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Disease relevance of PRNPIP

  • RESULTS: After a total docetaxel dose of 200 mg/m2, COPpl, COPint, and hemoglobin, hematocrit, albumin, and total protein values had decreased significantly; Pint and body weight were unchanged; and only mild edema was observed [1].
 

High impact information on PRNPIP

  • Transcapillary forces, ie, colloid osmotic pressure of plasma (COPpl) and interstitial fluid (COPint) and interstitial hydrostatic pressure (Pint), were measured before the start of treatment and after total docetaxel doses of 200 and 500 mg/m2 by means of the well-documented wick and wick-in-needle methods [1].
  • On stratified analysis, a significant increase in risk with asthma/atopy was restricted to those with the at-risk genotype (Pint < 0.05) [2].

References

  1. Capillary protein leak syndrome appears to explain fluid retention in cancer patients who receive docetaxel treatment. Semb, K.A., Aamdal, S., Oian, P. J. Clin. Oncol. (1998) [Pubmed]
  2. Joint effect of asthma/atopy and an IL-6 gene polymorphism on lung cancer risk among lifetime non-smoking Chinese women. Seow, A., Ng, D.P., Choo, S., Eng, P., Poh, W.T., Ming, T., Wang, Y.T. Carcinogenesis (2006) [Pubmed]
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