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MeSH Review

Osmotic Pressure

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Disease relevance of Osmotic Pressure


Psychiatry related information on Osmotic Pressure


High impact information on Osmotic Pressure

  • In crab muscle, however, unsampled myosin reflections can be obtained, and lattice spacing (between adjacent thick filaments) can be changed by osmotic pressure applied to chemically skinned single fibres [7].
  • Exposure to UV light or osmotic shock induced clustering and internalization of cell surface receptors for epidermal growth factor (EGF), tumor necrosis factor (TNF), and interleukin-1 (IL-1) [8].
  • Cells lacking Fus3 or Hog1 activity are deficient in mating or adaptation to osmotic shock, respectively [9].
  • Recognizing that osmotic pressure is a principal factor controlling antidiuresis, Verney introduced the term 'osmoreceptor' to designate the mysterious cerebral structures that regulate vasopressin release from the posterior pituitary [10].
  • Spontaneous Ca(2+) sparks can be reversibly induced by osmotic shock, and participate in a normal physiological response to exercise [11].

Chemical compound and disease context of Osmotic Pressure


Biological context of Osmotic Pressure


Anatomical context of Osmotic Pressure

  • The activation of TAK1 by TNF-alpha, IL-1 or osmotic shock was also enhanced in embryonic fibroblasts from SAPK2a/p38alpha-deficient mice, while incubation of these cells with SB 203580 had no effect [22].
  • Further, MNK1 was activated upon stimulation of HeLa cells with 12-O-tetradecanoylphorbol-13-acetate, fetal calf serum, anisomycin, UV irradiation, tumor necrosis factor-alpha, interleukin-1beta, or osmotic shock, and the activation by these stimuli was differentially inhibited by the MEK inhibitor PD098059 or the p38 MAP kinase inhibitor SB202190 [23].
  • After osmotic shock of the nerve endings, the activity was largely membrane associated and could not be released from membranes by freeze-thawing, dilution, 75 mM NaCl or 4 mM EDTA [24].
  • Critical steps for good quality of cryopreserved hepatocytes included the use of University of Wisconsin (UW) solution as a main component of the freezing medium, stepwise reduction of dimethylsulfoxide (DMSO) to avoid osmotic shock, and maintenance of low concentrations of DMSO in the culture medium [25].
  • We first showed that osmotic shock by 1 m sucrose stimulated rapid release of neurotransmitters from intact PC12 cells, indicating that most of the vesicles were docked at the plasma membrane [26].

Associations of Osmotic Pressure with chemical compounds

  • Plasma colloid osmotic pressure (PCOP) and echoencephalograms were monitored serially during and after labour in nine nulliparous severe pre-eclamptics receiving parenteral fluids, including infusions of magnesium sulphate and hydralazine [27].
  • DokA, a homolog of bacterial hybrid histidine kinases, is essential for hyperosmotic stress resistance in Dictyostelium: We show that a transient intracellular cAMP signal, dependent on the presence of DokA, is generated in response to an osmotic shock [28].
  • The effects of changes in external osmotic pressure were investigated by adding and removing mannitol from the bathing solution [29].
  • Psp is also synthesized transiently in response to several stresses (heat, ethanol, and osmotic shock) [30].
  • Lactose, together with other sugars and diffusible ions, is responsible for the osmotic pressure of milk [31].

Gene context of Osmotic Pressure

  • Co-transfection with SAPKK3 induced SAPK3 activity and greatly enhanced activation in response to osmotic shock [32].
  • We have analysed the transcriptional regulation of the TPS2 gene and have shown that its transcription is induced by a variety of stressful conditions caused by metabolic inhibitors, osmotic shock and heat shock [33].
  • One of these MAPKs, c-Jun N-terminal kinase (JNK), stimulates the transcriptional activity of c-Jun in response to growth factors, proinflammatory cytokines, and certain environmental stresses, such as short wavelength UV light or osmotic shock [34].
  • Furthermore, a hog1 mitogen-activated protein kinase deletion strain could not counteract repression on URSCRE-ENA1 during osmotic shock [35].
  • Yet, both rip1(-/-) and traf2(-/-) MEF exhibit a normal p38 MAP kinase response to inducers of osmotic shock or IL-1alpha [36].

Analytical, diagnostic and therapeutic context of Osmotic Pressure


  1. Stress-induced expression of the Escherichia coli phage shock protein operon is dependent on sigma 54 and modulated by positive and negative feedback mechanisms. Weiner, L., Brissette, J.L., Model, P. Genes Dev. (1991) [Pubmed]
  2. Effect of furosemide in canine low-pressure pulmonary edema. Ali, J., Chernicki, W., Wood, L.D. J. Clin. Invest. (1979) [Pubmed]
  3. Pulmonary edema during volume infusion. Stein, L., Beraud, J.J., Morissette, M., Luz, P.D., Weil, M.H., Shubin, H. Circulation (1975) [Pubmed]
  4. Osmotic loading of neutralizing antibodies demonstrates a role for protein-tyrosine phosphatase 1B in negative regulation of the insulin action pathway. Ahmad, F., Li, P.M., Meyerovitch, J., Goldstein, B.J. J. Biol. Chem. (1995) [Pubmed]
  5. Feeding- and chemical-related activity of ventromedial hypothalamic neurones in freely behaving rats. Ono, T., Sasaki, K., Shibata, R. J. Physiol. (Lond.) (1987) [Pubmed]
  6. Adrenal responses to chronic and acute water stress in Japanese quail Coturnix japonica. Tome, M.E., McNabb, F.M., Gwazdauskas, F.C. Comparative biochemistry and physiology. A, Comparative physiology. (1985) [Pubmed]
  7. The arrangement of myosin heads in relaxed crab muscle. Maéda, Y. Nature (1983) [Pubmed]
  8. Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Rosette, C., Karin, M. Science (1996) [Pubmed]
  9. A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase. Zhan, X.L., Guan, K.L. Genes Dev. (1999) [Pubmed]
  10. Osmoreception in magnocellular neurosecretory cells: from single channels to secretion. Oliet, S.H., Bourque, C.W. Trends Neurosci. (1994) [Pubmed]
  11. Uncontrolled calcium sparks act as a dystrophic signal for mammalian skeletal muscle. Wang, X., Weisleder, N., Collet, C., Zhou, J., Chu, Y., Hirata, Y., Zhao, X., Pan, Z., Brotto, M., Cheng, H., Ma, J. Nat. Cell Biol. (2005) [Pubmed]
  12. Blood volume prior to and following treatment of acute cardiogenic pulmonary edema. Figueras, J., Weil, M.H. Circulation (1978) [Pubmed]
  13. The critical role of the conserved Thr247 residue in the functioning of the osmosensor EnvZ, a histidine Kinase/Phosphatase, in Escherichia coli. Dutta, R., Yoshida, T., Inouye, M. J. Biol. Chem. (2000) [Pubmed]
  14. In Vitro system for the study of bacteriophage phi chi 174 adsorption and eclipse. Neuwald, P.D. J. Virol. (1975) [Pubmed]
  15. Shigella dysenteriae 1 cytotoxin: periplasmic protein releasable by polymyxin B and osmotic shock. Donohue-Rolfe, A., Keusch, G.T. Infect. Immun. (1983) [Pubmed]
  16. The function of a colloid in liver cold-storage preservation. Ar'Rajab, A., Ahrén, B., Sundberg, R., Bengmark, S. Transplantation (1991) [Pubmed]
  17. Rearrangement of cortex proteins constitutes an osmoprotective mechanism in Dictyostelium. Zischka, H., Oehme, F., Pintsch, T., Ott, A., Keller, H., Kellermann, J., Schuster, S.C. EMBO J. (1999) [Pubmed]
  18. Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent manner. Galvan, V., Roizman, B. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  19. Dentatorubral-pallidoluysian atrophy protein is phosphorylated by c-Jun NH2-terminal kinase. Okamura-Oho, Y., Miyashita, T., Nagao, K., Shima, S., Ogata, Y., Katada, T., Nishina, H., Yamada, M. Hum. Mol. Genet. (2003) [Pubmed]
  20. Cation channels trigger apoptotic death of erythrocytes. Lang, K.S., Duranton, C., Poehlmann, H., Myssina, S., Bauer, C., Lang, F., Wieder, T., Huber, S.M. Cell Death Differ. (2003) [Pubmed]
  21. pH-dependent fusion of vesicular stomatitis virus with Vero cells. Measurement by dequenching of octadecyl rhodamine fluorescence. Blumenthal, R., Bali-Puri, A., Walter, A., Covell, D., Eidelman, O. J. Biol. Chem. (1987) [Pubmed]
  22. Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha. Cheung, P.C., Campbell, D.G., Nebreda, A.R., Cohen, P. EMBO J. (2003) [Pubmed]
  23. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. Fukunaga, R., Hunter, T. EMBO J. (1997) [Pubmed]
  24. Subcellular distribution of calcium- and calmodulin-dependent myosin light chain phosphorylating activity in rat cerebral cortex. Edelman, A.M., Hunter, D.D., Hendrickson, A.E., Krebs, E.G. J. Neurosci. (1985) [Pubmed]
  25. Woodchuck hepatocytes remain permissive for hepadnavirus infection and mouse liver repopulation after cryopreservation. Dandri, M., Burda, M.R., Gocht, A., Török, E., Pollok, J.M., Rogler, C.E., Will, H., Petersen, J. Hepatology (2001) [Pubmed]
  26. Calcium regulation of exocytosis in PC12 cells. Chen, Y.A., Scales, S.J., Duvvuri, V., Murthy, M., Patel, S.M., Schulman, H., Scheller, R.H. J. Biol. Chem. (2001) [Pubmed]
  27. Serial plasma oncotic pressure levels and echoencephalography during and after delivery in severe pre-eclampsia. Zinaman, M., Rubin, J., Lindheimer, M.D. Lancet (1985) [Pubmed]
  28. Osmotic stress response in Dictyostelium is mediated by cAMP. Ott, A., Oehme, F., Keller, H., Schuster, S.C. EMBO J. (2000) [Pubmed]
  29. Osmotic effects on vacuolar ion release in guard cells. MacRobbie, E.A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  30. Phage shock protein, a stress protein of Escherichia coli. Brissette, J.L., Russel, M., Weiner, L., Model, P. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  31. Creation and phenotypic analysis of alpha-lactalbumin-deficient mice. Stinnakre, M.G., Vilotte, J.L., Soulier, S., Mercier, J.C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  32. Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38). Cuenda, A., Cohen, P., Buée-Scherrer, V., Goedert, M. EMBO J. (1997) [Pubmed]
  33. Yap1p, a yeast transcriptional activator that mediates multidrug resistance, regulates the metabolic stress response. Gounalaki, N., Thireos, G. EMBO J. (1994) [Pubmed]
  34. Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase. Wu, Z., Wu, J., Jacinto, E., Karin, M. Mol. Cell. Biol. (1997) [Pubmed]
  35. Repressors and upstream repressing sequences of the stress-regulated ENA1 gene in Saccharomyces cerevisiae: bZIP protein Sko1p confers HOG-dependent osmotic regulation. Proft, M., Serrano, R. Mol. Cell. Biol. (1999) [Pubmed]
  36. The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinase. Lee, T.H., Huang, Q., Oikemus, S., Shank, J., Ventura, J.J., Cusson, N., Vaillancourt, R.R., Su, B., Davis, R.J., Kelliher, M.A. Mol. Cell. Biol. (2003) [Pubmed]
  37. Regulation of albumin and alpha-fetoprotein gene expression by colloid osmotic pressure in human hepatoma cells. Tsutsumi, T., Nakao, K., Mitsuoka, S., Hamasaki, K., Tsuruta, S., Shima, M., Nakata, K., Tamaoki, T., Nagataki, S. Gastroenterology (1993) [Pubmed]
  38. In vivo substrate specificity of periplasmic disulfide oxidoreductases. Hiniker, A., Bardwell, J.C. J. Biol. Chem. (2004) [Pubmed]
  39. Physical association between the peribacteroid membrane and lipopolysaccharide from the bacteroid outer membrane in Rhizobium-infected pea root nodule cells. Bradley, D.J., Butcher, G.W., Galfre, G., Wood, E.A., Brewin, N.J. J. Cell. Sci. (1986) [Pubmed]
  40. Hypoalbuminemia in elderly patients with acute diastolic heart failure. Arquès, S., Ambrosi, P., Gélisse, R., Luccioni, R., Habib, G. J. Am. Coll. Cardiol. (2003) [Pubmed]
  41. Activation of the capacity for sodium-induced pinocytosis in Amoeba proteus. Johansson, P., Josefsson, J.O. Exp. Cell Res. (1984) [Pubmed]
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