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Gene Review

AIMP2  -  aminoacyl tRNA synthetase complex...

Homo sapiens

Synonyms: Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, JTV-1, JTV1, Multisynthase complex auxiliary component p38, P38, ...
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High impact information on JTV1

  • These results suggest that the conformational state of P38, controlled by Fpr4, is important for methylation of H3K36 by Set2 [1].
  • Analysis of the DNA mismatch repair-associated PMS2 gene, which overlaps at the genomic level with the JTV-1 gene, revealed PMS2 mRNA to be down-regulated in tumor spheroids, which was confirmed at the protein level [2].
  • Four genes (encoding Nop56, the NADH SDAP subunit, and two novel sequences) were found to be down-regulated in EMT-6 spheroids and four (encoding 2-oxoglutarate carrier protein, JTV-1, and two novel sequences) were up-regulated [2].
  • Biomarkers in pathways potentially affected by perifosine, including AKT, P-AKT, P38, p53 and p21 were measured on tumor tissue by immunohistochemistry by manual and automated methods [3].

Analytical, diagnostic and therapeutic context of JTV1

  • Although the sample size was small, a significant correlation was detected between high expression of P38 and AKT in baseline tumor tissue and better survival [3].


  1. Proline isomerization of histone h3 regulates lysine methylation and gene expression. Nelson, C.J., Santos-Rosa, H., Kouzarides, T. Cell (2006) [Pubmed]
  2. Gene expression analysis of tumor spheroids reveals a role for suppressed DNA mismatch repair in multicellular resistance to alkylating agents. Francia, G., Man, S., Teicher, B., Grasso, L., Kerbel, R.S. Mol. Cell. Biol. (2004) [Pubmed]
  3. A Phase II Trial of Perifosine, An Oral Alkylphospholipid, In Recurrent or Metastatic Head and Neck Cancer. Argiris, A., Cohen, E., Karrison, T., Esparaz, B., Mauer, A., Ansari, R., Wong, S., Lu, Y., Pins, M., Dancey, J., Vokes, E. Cancer Biol. Ther. (2006) [Pubmed]
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