Gene Review:
PMS2 - PMS2 postmeiotic segregation increased 2...
Homo sapiens
Synonyms:
DNA mismatch repair protein PMS2, HNPCC4, H_DJ0042M02.9, Mismatch repair endonuclease PMS2, PMS1 protein homolog 2, ...
Song,
Ramus,
Quaye,
Dicioccio,
Tyrer,
Lomas,
Shadforth,
Hogdall,
Hogdall,
McGuire,
Whittemore,
Easton,
Ponder,
Kjaer,
Pharoah,
Gayther,
Rüschoff,
Wallinger,
Dietmaier,
Bocker,
Brockhoff,
Hofstädter,
Fishel,
Hendriks,
Jagmohan-Changur,
van der Klift,
Morreau,
van Puijenbroek,
Tops,
van Os,
Wagner,
Ausems,
Gomez,
Breuning,
Bröcker-Vriends,
Vasen,
Wijnen,
- Immunohistochemical analysis reveals high frequency of PMS2 defects in colorectal cancer. Truninger, K., Menigatti, M., Luz, J., Russell, A., Haider, R., Gebbers, J.O., Bannwart, F., Yurtsever, H., Neuweiler, J., Riehle, H.M., Cattaruzza, M.S., Heinimann, K., Schär, P., Jiricny, J., Marra, G. Gastroenterology (2005)
- Heterozygous mutations in PMS2 cause hereditary nonpolyposis colorectal carcinoma (Lynch syndrome). Hendriks, Y.M., Jagmohan-Changur, S., van der Klift, H.M., Morreau, H., van Puijenbroek, M., Tops, C., van Os, T., Wagner, A., Ausems, M.G., Gomez, E., Breuning, M.H., Bröcker-Vriends, A.H., Vasen, H.F., Wijnen, J.T. Gastroenterology (2006)
- Common variants in mismatch repair genes and risk of invasive ovarian cancer. Song, H., Ramus, S.J., Quaye, L., Dicioccio, R.A., Tyrer, J., Lomas, E., Shadforth, D., Hogdall, E., Hogdall, C., McGuire, V., Whittemore, A.S., Easton, D.F., Ponder, B.A., Kjaer, S.K., Pharoah, P.D., Gayther, S.A. Carcinogenesis (2006)
- Mice defective in the DNA mismatch gene PMS2 are hypersensitive to MNU induced thymic lymphoma and are partially protected by transgenic expression of human MGMT. Qin, X., Liu, L., Gerson, S.L. Oncogene (1999)
- Endonucleolytic function of MutLalpha in human mismatch repair. Kadyrov, F.A., Dzantiev, L., Constantin, N., Modrich, P. Cell (2006)
- The molecular basis of Turcot's syndrome. Hamilton, S.R., Liu, B., Parsons, R.E., Papadopoulos, N., Jen, J., Powell, S.M., Krush, A.J., Berk, T., Cohen, Z., Tetu, B. N. Engl. J. Med. (1995)
- Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Baker, S.M., Bronner, C.E., Zhang, L., Plug, A.W., Robatzek, M., Warren, G., Elliott, E.A., Yu, J., Ashley, T., Arnheim, N., Flavell, R.A., Liskay, R.M. Cell (1995)
- Transgenic expression of human MGMT blocks the hypersensitivity of PMS2-deficient mice to low dose MNU thymic lymphomagenesis. Qin, X., Zhou, H., Liu, L., Gerson, S.L. Carcinogenesis (1999)
- Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selection. Rüschoff, J., Wallinger, S., Dietmaier, W., Bocker, T., Brockhoff, G., Hofstädter, F., Fishel, R. Proc. Natl. Acad. Sci. U.S.A. (1998)
- hMLH1 expression and cellular responses of ovarian tumour cells to treatment with cytotoxic anticancer agents. Brown, R., Hirst, G.L., Gallagher, W.M., McIlwrath, A.J., Margison, G.P., van der Zee, A.G., Anthoney, D.A. Oncogene (1997)
- Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. Mihaylova, V.T., Bindra, R.S., Yuan, J., Campisi, D., Narayanan, L., Jensen, R., Giordano, F., Johnson, R.S., Rockwell, S., Glazer, P.M. Mol. Cell. Biol. (2003)
- Mutator phenotype in human hematopoietic neoplasms and its association with deletions disabling DNA repair genes and bcl-2 rearrangements. Indraccolo, S., Minuzzo, S., Nicoletti, L., Cretella, E., Simon, M., Papakonstantinou, G., Hehlmann, R., Mion, M., Bertorelle, R., Roganovic, J., Chieco-Bianchi, L. Blood (1999)
- Microsatellite instability, immunohistochemistry, and additional PMS2 staining in suspected hereditary nonpolyposis colorectal cancer. de Jong, A.E., van Puijenbroek, M., Hendriks, Y., Tops, C., Wijnen, J., Ausems, M.G., Meijers-Heijboer, H., Wagner, A., van Os, T.A., Bröcker-Vriends, A.H., Vasen, H.F., Morreau, H. Clin. Cancer Res. (2004)
- Truncation of the mismatch repair protein PMS2 during the neoplastic transformation of human breast epithelial cells in vitro. Balogh, G.A., Russo, I.H., Russo, J. Int. J. Oncol. (2004)
- Truncation of the C-terminus of human MLH1 blocks intracellular stabilization of PMS2 and disrupts DNA mismatch repair. Mohd, A.B., Palama, B., Nelson, S.E., Tomer, G., Nguyen, M., Huo, X., Buermeyer, A.B. DNA Repair (Amst.) (2006)
- Sessile serrated adenomas with low- and high-grade dysplasia and early carcinomas: an immunohistochemical study of serrated lesions "caught in the act". Sheridan, T.B., Fenton, H., Lewin, M.R., Burkart, A.L., Iacobuzio-Donahue, C.A., Frankel, W.L., Montgomery, E. Am. J. Clin. Pathol. (2006)
- Molecular mechanisms associated with chromosomal and microsatellite instability in sporadic glioblastoma multiforme. Martinez, R., Schackert, H.K., Plaschke, J., Baretton, G., Appelt, H., Schackert, G. Oncology (2004)
- Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin. Shimodaira, H., Yoshioka-Yamashita, A., Kolodner, R.D., Wang, J.Y. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Analysis of the 5' region of PMS2 reveals heterogeneous transcripts and a novel overlapping gene. Nicolaides, N.C., Kinzler, K.W., Vogelstein, B. Genomics (1995)
- Contribution of human mlh1 and pms2 ATPase activities to DNA mismatch repair. Tomer, G., Buermeyer, A.B., Nguyen, M.M., Liskay, R.M. J. Biol. Chem. (2002)
- Structure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPase. Guarné, A., Junop, M.S., Yang, W. EMBO J. (2001)
- The interaction of the human MutL homologues in hereditary nonpolyposis colon cancer. Guerrette, S., Acharya, S., Fishel, R. J. Biol. Chem. (1999)
- Expression of the DNA mismatch repair proteins hMLH1 and hPMS2 in normal human tissues. Fink, D., Nebel, S., Aebi, S., Zheng, H., Kim, H.K., Christen, R.D., Howell, S.B. Br. J. Cancer (1997)
- DNA mismatch repair deficient mice in cancer research. Prolla, T.A., Abuin, A., Bradley, A. Semin. Cancer Biol. (1996)
- Mutagenesis of yeast MW104-1B strain has identified the uncharacterized PMS6 DNA mismatch repair gene locus and additional alleles of existing PMS1, PMS2 and MSH2 genes. Jeyaprakash, A., Welch, J.W., Fogel, S. Mutat. Res. (1994)
- Mismatch repair gene PMS2: disease-causing germline mutations are frequent in patients whose tumors stain negative for PMS2 protein, but paralogous genes obscure mutation detection and interpretation. Nakagawa, H., Lockman, J.C., Frankel, W.L., Hampel, H., Steenblock, K., Burgart, L.J., Thibodeau, S.N., de la Chapelle, A. Cancer Res. (2004)
- Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer. Wang, Q., Lasset, C., Desseigne, F., Saurin, J.C., Maugard, C., Navarro, C., Ruano, E., Descos, L., Trillet-Lenoir, V., Bosset, J.F., Puisieux, A. Hum. Genet. (1999)
- Characterization of the Interactome of the Human MutL Homologues MLH1, PMS1, and PMS2. Cannavo, E., Gerrits, B., Marra, G., Schlapbach, R., Jiricny, J. J. Biol. Chem. (2007)