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Gene Review

TTLL7  -  tubulin tyrosine ligase-like family member 7

Homo sapiens

Synonyms: FLJ23033, Testis development protein NYD-SP30, Tubulin polyglutamylase TTLL7, Tubulin--tyrosine ligase-like protein 7
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High impact information on TTLL7

  • Consistent with having a role in the growth of MAP2-positive neurites, TTLL7 accumulated within a MAP2-enriched somatodendritic portion of superior cervical ganglion, as did polyglutamylated beta-tubulin [1].
  • Following stimulation of PC12 cells with nerve growth factor to differentiate, the level of TTLL7 increased concomitantly with polyglutamylation of beta-tubulin [1].
  • Consistent with these findings, knockdown of TTLL7 in a primary culture of superior cervical ganglion neurons caused a loss of polyglutamylated beta-tubulin [1].

Anatomical context of TTLL7

  • TTLL7 Is a Mammalian beta-Tubulin Polyglutamylase Required for Growth of MAP2-positive Neurites [1].


  1. TTLL7 Is a Mammalian beta-Tubulin Polyglutamylase Required for Growth of MAP2-positive Neurites. Ikegami, K., Mukai, M., Tsuchida, J., Heier, R.L., Macgregor, G.R., Setou, M. J. Biol. Chem. (2006) [Pubmed]
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