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Gene Review

PREX2  -  phosphatidylinositol-3,4,5-trisphosphate...

Homo sapiens

Synonyms: 6230420N16Rik, DEP domain-containing protein 2, DEP.2, DEPDC2, FLJ12987, ...
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High impact information on DEPDC2

  • The contact interface between the PH domain of P-Rex2 and Rac1 involves the switch loop and helix 3 of Rac1 [1].
  • Despite having the ability to recognize this chimeric Cdc42, P-Rex2 is unable to catalyze nucleotide exchange on Cdc42, suggesting that recognition of substrate and catalysis are two distinct events [1].
  • P-Rex1 is mainly expressed in neutrophils and regulates reactive oxygen species formation in these cells (Welch et al., 2002), whereas P-Rex2 is expressed in a wide variety of tissues but not in neutrophils (Donald et al., 2004), and P-Rex2B is expressed in the heart (Rosenfeldt et al., 2004) [2].

Associations of DEPDC2 with chemical compounds

  • P-Rex1 and P-Rex2 also contain two DEP and two PDZ protein interaction domains, as well as homology over their COOH-terminal half to inositol polyphosphate 4-phosphatase (Donald et al., 2004; Welch et al., 2002) [2].


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