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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Table of contents

About

Terms

 

Gene Review: 

CALM3  -  calmodulin 3 (phosphorylase kinase, delta)

Homo sapiens

Synonyms: HEL-S-72, PHKD, PHKD3
 
 
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High impact information on CALM3

  • We found that all these cell lines (except Ramos) overexpressed CALM3 transcripts, which led to an increase of total CaM protein with respect to quiescent normal T lymphocytes [1].
  • Human calmodulin is encoded by three genes CALM1, CALM2 and CALM3 located on different chromosomes [2].
  • From APOE to CALM3 (approximately 2 Mb), the average marker spacing was approximately 30 kb [3].
  • Intron interruptions were found at identical positions in human CALM2 as in CALM1 and CALM3; however, the overall size of CALM2 (16 kb) was almost twice that of the other two human CALM genes [2].
  • Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3 [4].
 

Biological context of CALM3

 

Other interactions of CALM3

  • Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1, CALM2 and CALM3 [2].

References

  1. Expression of calmodulin and calmodulin binding proteins in lymphoblastoid cells. Colomer, J., Agell, N., Engel, P., Bachs, O. J. Cell. Physiol. (1994) [Pubmed]
  2. Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1, CALM2 and CALM3. Toutenhoofd, S.L., Foletti, D., Wicki, R., Rhyner, J.A., Garcia, F., Tolon, R., Strehler, E.E. Cell Calcium (1998) [Pubmed]
  3. A 4-Mb high-density single nucleotide polymorphism-based map around human APOE. Lai, E., Riley, J., Purvis, I., Roses, A. Genomics (1998) [Pubmed]
  4. Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3. Berchtold, M.W., Egli, R., Rhyner, J.A., Hameister, H., Strehler, E.E. Genomics (1993) [Pubmed]
  5. Mutation analysis of chromosome 19 calmodulin (CALM3) gene in Alzheimer's disease patients. Ibarreta, D., Tao, J., Parrilla, R., Ayuso, M.S. Neurosci. Lett. (1997) [Pubmed]
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