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Gene Review

CALM2  -  calmodulin 2 (phosphorylase kinase, delta)

Homo sapiens

Synonyms: CAMII, PHKD, PHKD2
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Disease relevance of CALM2


High impact information on CALM2

  • Calmodulin is encoded in vertebrates by three different genes: CALM1, CALM2, and CALM3 [2].
  • Denervation led to modest decreases in the levels of mRNAs for both CAMII and MAP2 but did not lead to detectable alterations in mRNA distribution [3].
  • The mRNA encoding the alpha subunit of calcium/calmodulin dependent protein kinase II (CAMII kinase) was present at high levels throughout the layers that contain the dendrites of hippocampal pyramidal cells and dentate granule cells [3].
  • Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3 [4].
  • The three bona fide genes coding for calmodulin CALM1, CALM2, and CALM3, were assigned to human chromosomes 14, 2, and 19, respectively, by polymerase chain reaction-based amplification of calmodulin gene-specific sequences using DNA from human-hamster cell hybrids as template [4].

Biological context of CALM2

  • Conversely, levels of immunocytochemically detectable calcium-calmodulin-dependent protein kinase (CAMII kinase) are increased in deprived eye dominance columns [5].


  1. High expression of calcium-binding proteins, S100A10, S100A11 and CALM2 in anaplastic large cell lymphoma. Rust, R., Visser, L., van der Leij, J., Harms, G., Blokzijl, T., Deloulme, J.C., van der Vlies, P., Kamps, W., Kok, K., Lim, M., Poppema, S., van den Berg, A. Br. J. Haematol. (2005) [Pubmed]
  2. Expression of calmodulin and calmodulin binding proteins in lymphoblastoid cells. Colomer, J., Agell, N., Engel, P., Bachs, O. J. Cell. Physiol. (1994) [Pubmed]
  3. mRNA distribution within dendrites: relationship to afferent innervation. Steward, O., Wallace, C.S. J. Neurobiol. (1995) [Pubmed]
  4. Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3. Berchtold, M.W., Egli, R., Rhyner, J.A., Hameister, H., Strehler, E.E. Genomics (1993) [Pubmed]
  5. The role of afferent activity in the maintenance of primate neocorticalfunction. Jones, E.G. J. Exp. Biol. (1990) [Pubmed]
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