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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TMPRSS5  -  transmembrane protease, serine 5

Homo sapiens

Synonyms: MGC141886, MGC148044, Spinesin, Transmembrane protease serine 5
 
 
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High impact information on TMPRSS5

  • Spinesin/TMPRSS5, a novel transmembrane serine protease, cloned from human spinal cord [1].
  • A homology search revealed that the human spinesin gene was located at chromosome 11q23 and contained 13 exons, the gene structure being similar to that of TMPRSS3 whose gene is also located on 11q23 [1].
  • Spinesin has a simple type II transmembrane structure, consisting of, from the N terminus, a short cytoplasmic domain, a transmembrane domain, a stem region containing a scavenger receptor-like domain, and a serine protease domain [1].
  • A cDNA encoding a novel serine protease, which we designated spinesin, has been cloned from human spinal cord [1].
 

Analytical, diagnostic and therapeutic context of TMPRSS5

  • Northern blot analysis against mRNA from human tissues including liver, lung, placenta, and heart demonstrated a specific expression of spinesin mRNA in the brain [1].

References

  1. Spinesin/TMPRSS5, a novel transmembrane serine protease, cloned from human spinal cord. Yamaguchi, N., Okui, A., Yamada, T., Nakazato, H., Mitsui, S. J. Biol. Chem. (2002) [Pubmed]
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