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YIPF5  -  Yip1 domain family, member 5

Homo sapiens

Synonyms: FINGER5, FinGER5, Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 5, PP12723, Protein YIPF5, ...
 
 
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High impact information on YIPF5

  • The highest level of expression was found in coronary smooth muscle cells, in which expression of the SMAP-5 gene was induced by transforming growth factor beta1, thus indicating that this protein may play an important role in inflammation [1].
  • The human SMAP-5 gene spans about 12.5 kb and comprises 6 exons on chromosomal locus 5q32 [1].
  • SMAP-5 is a member of the five-pass transmembrane protein family localizing in the Golgi apparatus and the endoplasmic reticulum [1].
  • The amino acid sequence and the GATA1-binding capacity of the human and murine finger 5 are however different [2].
  • Use of the various truncated ZNF219 constructs demonstrated that zinc finger 1 to 3 or zinc finger 5 and 6 domains are sufficient to allow specific DNA binding [3].
 

Analytical, diagnostic and therapeutic context of YIPF5

  • The power of the pain-evoked brain potentials elicited from finger 3 was lower (P less than 0.05) compared to finger 5, and compared to the control group (P less than 0.01) [4].

References

  1. Cloning, cellular localization, genomic organization, and tissue-specific expression of the TGFbeta1-inducible SMAP-5 gene. Stolle, K., Schnoor, M., Fuellen, G., Spitzer, M., Engel, T., Spener, F., Cullen, P., Lorkowski, S. Gene (2005) [Pubmed]
  2. Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions. Freson, K., Thys, C., Wittewrongel, C., Vermylen, J., Hoylaerts, M.F., Van Geet, C. Hum. Genet. (2003) [Pubmed]
  3. Identification of the DNA binding specificity of the human ZNF219 protein and its function as a transcriptional repressor. Sakai, T., Hino, K., Wada, S., Maeda, H. DNA Res. (2003) [Pubmed]
  4. Involvement of thin afferents in carpal tunnel syndrome: evaluated quantitatively by argon laser stimulation. Arendt-Nielsen, L., Gregersen, H., Toft, E., Bjerring, P. Muscle Nerve (1991) [Pubmed]
 
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