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Gene Review

COL21A1  -  collagen, type XXI, alpha 1

Homo sapiens

Synonyms: COL1AL, COLA1L, Collagen alpha-1(XXI) chain, FP633, dJ682J15.1, ...
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High impact information on COL21A1

  • COL21A1 is localized to chromosome 6p11.2-12.3, spanning 337 kb in size [1].
  • Platelet-derived growth factor (PDGF) has a pronounced effect on the stimulation of COL21A1 expression in cultured aortic smooth-muscle cells, suggesting that alpha1(XXI) collagen may contribute to the extracellular matrix assembly of the vascular network during blood vessel formation [1].
  • Bioinformatics analysis of cDNA clone DKFZp564B052 showed that it resembled the FACIT collagens and was therefore designated collagen alpha 1(XXI) [2].
  • Expression analysis indicated that COL21A1 mRNA is present in many tissues including heart, stomach, kidney, skeletal muscle and placenta, and radiation hybrid mapping localized the COL21A1 gene to 6p11-12 [3].
  • Analysis of the nucleotide sequences of three BAC clones that included the rearrangement point demonstrated that COL21A1 and DST, which were not present in the corresponding human region, were located adjacent to the rearrangement point [4].


  1. Genomic organization and characterization of the human type XXI collagen (COL21A1) gene. Chou, M.Y., Li, H.C. Genomics (2002) [Pubmed]
  2. Identification and analysis of collagen alpha 1(XXI), a novel member of the FACIT collagen family. Tuckwell, D. Matrix Biol. (2002) [Pubmed]
  3. A new FACIT of the collagen family: COL21A1. Fitzgerald, J., Bateman, J.F. FEBS Lett. (2001) [Pubmed]
  4. Genomic structure and gene order of swine chromosome 7q1.1-->q1.2. Tanaka, M., Suzuki, K., Morozumi, T., Kobayashi, E., Matsumoto, T., Domukai, M., Eguchi-Ogawa, T., Shinkai, H., Awata, T., Uenishi, H. Anim. Genet. (2006) [Pubmed]
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