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Gene Review

TSSK3  -  testis-specific serine kinase 3

Homo sapiens

Synonyms: SPOGA3, STK22C, STK22D, Serine/threonine-protein kinase 22C, TSK-3, ...
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High impact information on TSSK3

  • We then cloned the human homologue of this protein kinase gene (STK22C) and found it to be expressed exclusively in the testis [1].
  • We cloned human and mouse TSSK3 and analysed the biochemical properties, substrate specificity and in vitro activation [2].
  • Sequence comparison indicated the existence of a so-called 'T-loop' within the TSSK3 catalytic domain, a structure present in the AGC family of protein kinases [2].
  • Analysis of peptide sequences identifies the peptide sequence RRSSSY containing Ser5 that is a target for TSSK3 phosphorylation, as an efficient and specific substrate for TSSK3 [2].

Anatomical context of TSSK3

  • Interestingly, TSSK3 showed maximal in vitro kinase activity at 30 degrees C, in keeping with it being testis specific [2].


  1. Cloning and chromosomal localization of a gene encoding a novel serine/threonine kinase belonging to the subfamily of testis-specific kinases. Visconti, P.E., Hao, Z., Purdon, M.A., Stein, P., Balsara, B.R., Testa, J.R., Herr, J.C., Moss, S.B., Kopf, G.S. Genomics (2001) [Pubmed]
  2. Characterization of testis-specific serine-threonine kinase 3 and its activation by phosphoinositide-dependent kinase-1-dependent signalling. Bucko-Justyna, M., Lipinski, L., Burgering, B.M., Trzeciak, L. FEBS J. (2005) [Pubmed]
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