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Gene Review

Msx1  -  msh homeobox 1

Rattus norvegicus

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Disease relevance of Msx1

  • In this study, by the combined application of mutagenesis and site-specific protein recognition analysis, we examined interactions of ROS 17/2.8 osteosarcoma cell nuclear proteins and purified Msx-1 homeodomain protein with the OC box [1].

High impact information on Msx1

  • We detected a series of related specific protein-DNA interactions, a subset of which were inhibited by antibodies directed against the Msx-1 homeodomain but which also recognize the Msx-2 homeodomain [1].
  • In transient transfection experiments, Msx-1 potently inhibited pituitary homeobox-1 (Pitx-1)-induced MT(1) promoter activity and therefore may represent a key inhibitor of MT(1) expression in early pituitary development [2].


  1. Transcriptional control of the tissue-specific, developmentally regulated osteocalcin gene requires a binding motif for the Msx family of homeodomain proteins. Hoffmann, H.M., Catron, K.M., van Wijnen, A.J., McCabe, L.R., Lian, J.B., Stein, G.S., Stein, J.L. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. Regulation of MT melatonin receptor expression in the foetal rat pituitary. Johnston, J.D., Klosen, P., Barrett, P., Hazlerigg, D.G. J. Neuroendocrinol. (2006) [Pubmed]
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