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Gene Review

Pitx1  -  paired-like homeodomain 1

Rattus norvegicus

Synonyms: Homeobox protein PITX1, Paired-like homeodomain transcription factor 1, Pituitary homeobox 1, Ptx1
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High impact information on Pitx1


Regulatory relationships of Pitx1

  • In transient transfection experiments, Msx-1 potently inhibited pituitary homeobox-1 (Pitx-1)-induced MT(1) promoter activity and therefore may represent a key inhibitor of MT(1) expression in early pituitary development [4].

Other interactions of Pitx1

  • In contrast, functional interaction between Pitx1 and Egr-1 persisted with mutation of both Pitx1 regions [3].

Analytical, diagnostic and therapeutic context of Pitx1


  1. Pituitary homeobox 1 activates the rat FSHbeta (rFSHbeta) gene through both direct and indirect interactions with the rFSHbeta gene promoter. Zakaria, M.M., Jeong, K.H., Lacza, C., Kaiser, U.B. Mol. Endocrinol. (2002) [Pubmed]
  2. Characterization of 5'-flanking region of rat somatostatin receptor sst2 gene: transcriptional regulatory elements and activation by Pitx1 and estrogen. Kimura, N., Tomizawa, S., Arai, K.N., Osamura, R.Y., Kimura, N. Endocrinology (2001) [Pubmed]
  3. Pituitary homeobox 1 (Pitx1) stimulates rat LHbeta gene expression via two functional DNA-regulatory regions. Jiang, Q., Jeong, K.H., Horton, C.D., Halvorson, L.M. J. Mol. Endocrinol. (2005) [Pubmed]
  4. Regulation of MT melatonin receptor expression in the foetal rat pituitary. Johnston, J.D., Klosen, P., Barrett, P., Hazlerigg, D.G. J. Neuroendocrinol. (2006) [Pubmed]
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