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Gene Review

Snrpn  -  small nuclear ribonucleoprotein polypeptide N

Rattus norvegicus

Synonyms: FE 294, FE 294 psi, FE294, FE294 psi, Sm protein D, ...
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High impact information on Snrpn


Biological context of Snrpn

  • Although a role for SmN in modulating tissue specific alternative splicing decisions in the heart and brain has been suggested, its precise function and the processes regulating its expression remain unclear [2].

Associations of Snrpn with chemical compounds

  • These findings are discussed in terms of the regulation of SmN expression and the potential role of this factor in the response of cardiac cells to members of the steroid/thyroid hormone family [2].

Analytical, diagnostic and therapeutic context of Snrpn

  • This increase in SmN levels is dependent upon a corresponding increase in the SmN mRNA which is detectable by in situ hybridization within neurons in virtually all areas of the adult brain [1].


  1. Expression of the SmN splicing protein is developmentally regulated in the rodent brain but not in the rodent heart. Grimaldi, K., Horn, D.A., Hudson, L.D., Terenghi, G., Barton, P., Polak, J.M., Latchman, D.S. Dev. Biol. (1993) [Pubmed]
  2. Antagonistic effects of retinoic acid and thyroid hormone on the expression of the tissue-specific splicing protein SmN in a clonal cell line derived from rat heart. Gerrelli, D., Huntriss, J.D., Latchman, D.S. J. Mol. Cell. Cardiol. (1994) [Pubmed]
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