High impact information on Snrpn

• The SmN protein is a tissue-specific splicing factor which is closely related to the ubiquitous SmB splicing protein but which is expressed only in the adult brain and heart [1].
• Expression of the SmN splicing protein is developmentally regulated in the rodent brain but not in the rodent heart [1].
• In particular thyroid hormone and retinoic acid exhibit antagonistic effects on SmN expression with thyroid hormone treatment producing large increases in expression whilst retinoic acid treatment virtually abolishes expression [2].
• We show here that SmN is expressed in the H9c2 clonal cell line derived from rat heart and that its expression in these cells is affected by a variety of members of the steroid/thyroid hormone family [2].
• Antagonistic effects of retinoic acid and thyroid hormone on the expression of the tissue-specific splicing protein SmN in a clonal cell line derived from rat heart [2].

Biological context of Snrpn

• Although a role for SmN in modulating tissue specific alternative splicing decisions in the heart and brain has been suggested, its precise function and the processes regulating its expression remain unclear [2].

Associations of Snrpn with chemical compounds

• These findings are discussed in terms of the regulation of SmN expression and the potential role of this factor in the response of cardiac cells to members of the steroid/thyroid hormone family [2].

Analytical, diagnostic and therapeutic context of Snrpn

• This increase in SmN levels is dependent upon a corresponding increase in the SmN mRNA which is detectable by in situ hybridization within neurons in virtually all areas of the adult brain [1].

References