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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ORC2  -  origin recognition complex subunit 2

Arabidopsis thaliana

Synonyms: ATORC2, F13M22.6, F13M22_6, ORIGIN RECOGNITION COMPLEX SECOND LARGEST SUBUNIT 2, origin recognition complex second largest subunit 2
 
 
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High impact information on ATORC2/ORC2

  • The orc2 mutant phenotype is partly suppressed by a mutation in the Polycomb group gene MEDEA [1].
  • Nuclear division in the endosperm is arrested at an earlier developmental stage: only approximately four nuclei are detected in orc2 endosperm [1].
  • The highest levels of ORC2 gene expression were found in preglobular embryos, coinciding with the stage at which homozygous orc2 mutant seeds arrest [1].
  • Either alterations in chromatin structure or the release of cell cycle checkpoints by the mea mutation may allow more cell and nuclear divisions to occur in orc2 homozygous seeds [1].
  • The endosperm nuclei in orc2 are dramatically enlarged, a phenotype that is most similar to class B titan mutants, which include mutants in structural maintenance of chromosomes (SMC) cohesins [1].

References

  1. Genetic interaction of an origin recognition complex subunit and the Polycomb group gene MEDEA during seed development. Collinge, M.A., Spillane, C., Köhler, C., Gheyselinck, J., Grossniklaus, U. Plant Cell (2004) [Pubmed]
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