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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

FLK  -  RNA-binding KH domain-containing protein

Arabidopsis thaliana

Synonyms: F7O18.9, F7O18_9, flowering locus KH domain
 
 
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High impact information on FLK

  • These observations demonstrate that FLK regulates the autonomous flowering pathway via FLC [1].
  • In this study, an Arabidopsis (Arabidopsis thaliana) gene, designated FLK, was identified and shown to encode a putative RNA binding protein with K homology motifs [1].
  • A mutant in which FLK was inactivated by T-DNA insertion exhibited a severe late flowering phenotype both in long and short days [1].
  • In addition to FLK, the expression of two other KH domain genes are modestly affected by the flk mutation, suggesting a possible involvement of more than one KH domain protein in the regulation of flowering time in Arabidopsis [2].
 

Other interactions of FLK

  • FLK functions primarily as a repressor of FLC expression, although it also modestly affects expression of genes associated with the photoperiodic pathway [2].

References

  1. A new Arabidopsis gene, FLK, encodes an RNA binding protein with K homology motifs and regulates flowering time via FLOWERING LOCUS C. Lim, M.H., Kim, J., Kim, Y.S., Chung, K.S., Seo, Y.H., Lee, I., Kim, J., Hong, C.B., Kim, H.J., Park, C.M. Plant Cell (2004) [Pubmed]
  2. Regulation of flowering time in Arabidopsis by K homology domain proteins. Mockler, T.C., Yu, X., Shalitin, D., Parikh, D., Michael, T.P., Liou, J., Huang, J., Smith, Z., Alonso, J.M., Ecker, J.R., Chory, J., Lin, C. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
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