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Gene Review:

MSH7 - DNA mismatch repair protein Msh6-2

Arabidopsis thaliana

Synonyms: ARABIDOPSIS THALIANA MUTS HOMOLOG 7, ATMSH7, MSH6-2, MUTS HOMOLOG 6-2, MUTS homolog 7

Wu, S.Y. et al., Adé, J. et al., Culligan, K.M. et al.

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High impact information on MSH7

A novel feature in Arabidopsis is the presence of two MSH6-like proteins, designated AtMSH6 and AtMSH7 [1].
Southern analysis revealed that the three genes we have isolated exist as single copies, and genetic mapping indicated that AtMSH2 and AtMSH6-2 both reside on chromosome III [2].
To test hypotheses that MSH7 might be specialized for G/T, or for base mismatches in 5-methylcytosine contexts, we compared binding of AtMutSalpha and AtMutSgamma to a series of mismatched DNA oligoduplexes, relative to their (roughly similar) binding to G/T DNA [3].

References

Arabidopsis MutS homologs-AtMSH2, AtMSH3, AtMSH6, and a novel AtMSH7-form three distinct protein heterodimers with different specificities for mismatched DNA. Culligan, K.M., Hays, J.B. Plant Cell (2000) [Pubmed]
Four mismatch repair paralogues coexist in Arabidopsis thaliana: AtMSH2, AtMSH3, AtMSH6-1 and AtMSH6-2. Adé, J., Belzile, F., Philippe, H., Doutriaux, M.P. Mol. Gen. Genet. (1999) [Pubmed]
Dissimilar mispair-recognition spectra of Arabidopsis DNA-mismatch-repair proteins MSH2*MSH6 (MutSalpha) and MSH2*MSH7 (MutSgamma). Wu, S.Y., Culligan, K., Lamers, M., Hays, J. Nucleic Acids Res. (2003) [Pubmed]

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