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Gene Review

MSH2  -  DNA mismatch repair protein Msh2

Arabidopsis thaliana

Synonyms: ATMSH2, MUTS homolog 2
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High impact information on MSH2


Associations of MSH2 with chemical compounds

  • The Arabidopsis thaliana MSH2 (AtMSH2) gene encodes a protein that belongs to a family of highly conserved proteins (MutS homologues (MSH)) involved in DNA mismatch repair [4].

Other interactions of MSH2

  • Comparative analysis of the AtMSH2 Landsberg erecta genomic sequence (reported here) and the previously described AtMSH2 Columbia allele revealed several polymorphisms, including the presence of a small, transposon-like element in the 3' untranscribed region of the former allele [3].

Analytical, diagnostic and therapeutic context of MSH2

  • Sequence analysis strongly suggests that this single copy gene is indeed a homologue of MSH2, a gene known to play a central role in eukaryotic mismatch repair [4].
  • Second, gel retardation assays revealed that the AtMSH2 protein has a 10-fold greater affinity for DNA containing a single pair of mismatched nucleotides versus perfectly matched DNA [4].


  1. The role of AtMSH2 in homologous recombination in Arabidopsis thaliana. Emmanuel, E., Yehuda, E., Melamed-Bessudo, C., Avivi-Ragolsky, N., Levy, A.A. EMBO Rep. (2006) [Pubmed]
  2. Reduction of stability of arabidopsis genomic and transgenic DNA-repeat sequences (microsatellites) by inactivation of AtMSH2 mismatch-repair function. Leonard, J.M., Bollmann, S.R., Hays, J.B. Plant Physiol. (2003) [Pubmed]
  3. Four mismatch repair paralogues coexist in Arabidopsis thaliana: AtMSH2, AtMSH3, AtMSH6-1 and AtMSH6-2. Adé, J., Belzile, F., Philippe, H., Doutriaux, M.P. Mol. Gen. Genet. (1999) [Pubmed]
  4. Functional analysis of the Arabidopsis thaliana mismatch repair gene MSH2. Adé, J., Haffani, Y., Beizile, F.J. Genome (2001) [Pubmed]
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