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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ARA6  -  Rab-like GTP-ase

Arabidopsis thaliana

Synonyms: ARA-6, ATRAB5C, ATRABF1, RABF1
 
 
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High impact information on ARA6

  • Examination of green fluorescent protein (GFP)-tagged proteins indicates that both Ara6 and Ara7 are distributed on a subpopulation of endosomes and suggests their roles in endosomal fusion [1].
  • Ara6 is tightly associated with membranes and is expressed constitutively [1].
  • The endosomal localization of Ara6 requires N-terminal fatty acylation, nucleotide binding and the C-terminal amino acid sequence coordinately [1].
  • Arabidopsis sterol endocytosis involves actin-mediated trafficking via ARA6-positive early endosomes [2].
  • Sterols can be internalized from the plasma membrane and localize to endosomes positive for the early endosomal Rab5 GTPase homolog ARA6 fused to green fluorescent protein (GFP) (ARA6-GFP) [2].

References

  1. Ara6, a plant-unique novel type Rab GTPase, functions in the endocytic pathway of Arabidopsis thaliana. Ueda, T., Yamaguchi, M., Uchimiya, H., Nakano, A. EMBO J. (2001) [Pubmed]
  2. Arabidopsis sterol endocytosis involves actin-mediated trafficking via ARA6-positive early endosomes. Grebe, M., Xu, J., Möbius, W., Ueda, T., Nakano, A., Geuze, H.J., Rook, M.B., Scheres, B. Curr. Biol. (2003) [Pubmed]
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