Gene Review:
ATK5 - kinesin 5
Arabidopsis thaliana
Synonyms:
C17L7.110, C17L7_110
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Psychiatry related information on ATK5
- This +TIP activity is conferred by regions outside of the C-terminal motor domain, which reveals the presence of independent plus-end tracking and minus-end motor activities within ATK5 [1].
High impact information on ATK5
- Notably, in Arabidopsis interphase cells, YFP::ATK5 localizes to microtubules with a preferential enrichment at growing plus-ends; indicating ATK5 is a plus-end tracking protein (+TIP) [1].
Anatomical context of ATK5
- Based on these data, we propose a model in which ATK5 uses plus-end tracking to reach spindle midzones, where it then organizes microtubules via minus-end-directed motor activity [1].
References
- A minus-end-directed kinesin with plus-end tracking protein activity is involved in spindle morphogenesis. Ambrose, J.C., Li, W., Marcus, A., Ma, H., Cyr, R. Mol. Biol. Cell (2005) [Pubmed]
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