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Gene Review

ATK1  -  kinesin-like motor protein heavy chain

Arabidopsis thaliana

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Disease relevance of ATK1

  • A truncated KatC polypeptide (KatC(207-754)), which includes the carboxyl-terminal region of KatC, was expressed in Escherichia coli and was shown to possess microtubule-stimulated ATPase activity and to bind to microtubules in an ATP-sensitive manner, both of which are characteristics of kinesin and kinesin-like proteins [1].

Psychiatry related information on ATK1


High impact information on ATK1


Biological context of ATK1


Anatomical context of ATK1


Associations of ATK1 with chemical compounds

  • Unlike kinesin, cosedimentation of eIF-(iso)4F with MTs was neither reduced by MgATP nor enhanced by adenosine 5'-[gamma-imido]triphosphate [13].

Physical interactions of ATK1

  • A homolog of PKCBP from Arabidopsis (AKCBP) showed identical structural organization indicating that kinesin heavy chains that bind to calmodulin are likely to exist in other plants [14].

Regulatory relationships of ATK1

  • Molecular analysis reveals that the HINKEL gene encodes a plant-specific kinesin-related protein with a putative N-terminal motor domain and is expressed in a cell cycle-dependent manner similar to the KNOLLE gene [15].
  • Functional studies with ZWICHEL ( ZWI ), which encodes a Ca(2+)-calmodulin-regulated kinesin, have shown its involvement in trichome morphogenesis and cell division [16].
  • A novel calcium/calmodulin-regulated kinesin-like protein is highly conserved between monocots and dicots [17].

Other interactions of ATK1


  1. Sequencing and characterization of the kinesin-related genes katB and katC of Arabidopsis thaliana. Mitsui, H., Nakatani, K., Yamaguchi-Shinozaki, K., Shinozaki, K., Nishikawa, K., Takahashi, H. Plant Mol. Biol. (1994) [Pubmed]
  2. Arabidopsis thaliana protein, ATK1, is a minus-end directed kinesin that exhibits non-processive movement. Marcus, A.I., Ambrose, J.C., Blickley, L., Hancock, W.O., Cyr, R.J. Cell Motil. Cytoskeleton (2002) [Pubmed]
  3. Expansion of the cell plate in plant cytokinesis requires a kinesin-like protein/MAPKKK complex. Nishihama, R., Soyano, T., Ishikawa, M., Araki, S., Tanaka, H., Asada, T., Irie, K., Ito, M., Terada, M., Banno, H., Yamazaki, Y., Machida, Y. Cell (2002) [Pubmed]
  4. A kinesin-like protein is essential for oriented deposition of cellulose microfibrils and cell wall strength. Zhong, R., Burk, D.H., Morrison, W.H., Ye, Z.H. Plant Cell (2002) [Pubmed]
  5. Three-dimensional analysis of syncytial-type cell plates during endosperm cellularization visualized by high resolution electron tomography. Otegui, M.S., Mastronarde, D.N., Kang, B.H., Bednarek, S.Y., Staehelin, L.A. Plant Cell (2001) [Pubmed]
  6. A novel plant kinesin-related protein specifically associates with the phragmoplast organelles. Lee, Y.R., Giang, H.M., Liu, B. Plant Cell (2001) [Pubmed]
  7. The Arabidopsis ATK1 gene is required for spindle morphogenesis in male meiosis. Chen, C., Marcus, A., Li, W., Hu, Y., Calzada, J.P., Grossniklaus, U., Cyr, R.J., Ma, H. Development (2002) [Pubmed]
  8. A kinesin mutant with an atypical bipolar spindle undergoes normal mitosis. Marcus, A.I., Li, W., Ma, H., Cyr, R.J. Mol. Biol. Cell (2003) [Pubmed]
  9. Identification of a gene family (kat) encoding kinesin-like proteins in Arabidopsis thaliana and the characterization of secondary structure of KatA. Mitsui, H., Yamaguchi-Shinozaki, K., Shinozaki, K., Nishikawa, K., Takahashi, H. Mol. Gen. Genet. (1993) [Pubmed]
  10. An internal motor kinesin is associated with the Golgi apparatus and plays a role in trichome morphogenesis in Arabidopsis. Lu, L., Lee, Y.R., Pan, R., Maloof, J.N., Liu, B. Mol. Biol. Cell (2005) [Pubmed]
  11. Localization of two homologous Arabidopsis kinesin-related proteins in the phragmoplast. Pan, R., Lee, Y.R., Liu, B. Planta (2004) [Pubmed]
  12. AtKP1, a kinesin-like protein, mainly localizes to mitochondria in Arabidopsis thaliana. Ni, C.Z., Wang, H.Q., Xu, T., Qu, Z., Liu, G.Q. Cell Res. (2005) [Pubmed]
  13. Function of the p86 subunit of eukaryotic initiation factor (iso)4F as a microtubule-associated protein in plant cells. Bokros, C.L., Hugdahl, J.D., Kim, H.H., Hanesworth, V.R., van Heerden, A., Browning, K.S., Morejohn, L.C. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  14. A plant kinesin heavy chain-like protein is a calmodulin-binding protein. Reddy, A.S., Narasimhulu, S.B., Safadi, F., Golovkin, M. Plant J. (1996) [Pubmed]
  15. The Arabidopsis HINKEL gene encodes a kinesin-related protein involved in cytokinesis and is expressed in a cell cycle-dependent manner. Strompen, G., El Kasmi, F., Richter, S., Lukowitz, W., Assaad, F.F., Jürgens, G., Mayer, U. Curr. Biol. (2002) [Pubmed]
  16. Developmental and cell-specific expression of ZWICHEL is regulated by the intron and exon sequences of its gene. Reddy, V.S., Reddy, A.S. Plant Mol. Biol. (2004) [Pubmed]
  17. A novel calcium/calmodulin-regulated kinesin-like protein is highly conserved between monocots and dicots. Abdel-Ghany, S.E., Reddy, A.S. DNA Cell Biol. (2000) [Pubmed]
  18. Extragenic suppressors of the arabidopsis zwi-3 mutation identify new genes that function in trichome branch formation and pollen tube growth. Krishnakumar, S., Oppenheimer, D.G. Development (1999) [Pubmed]
  19. The Arabidopsis lue1 mutant defines a katanin p60 ortholog involved in hormonal control of microtubule orientation during cell growth. Bouquin, T., Mattsson, O., Naested, H., Foster, R., Mundy, J. J. Cell. Sci. (2003) [Pubmed]
  20. The AtNACK1/HINKEL and STUD/TETRASPORE/AtNACK2 genes, which encode functionally redundant kinesins, are essential for cytokinesis in Arabidopsis. Tanaka, H., Ishikawa, M., Kitamura, S., Takahashi, Y., Soyano, T., Machida, C., Machida, Y. Genes Cells (2004) [Pubmed]
  21. In vitro motility of AtKCBP, a calmodulin-binding kinesin protein of Arabidopsis. Song, H., Golovkin, M., Reddy, A.S., Endow, S.A. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  22. A novel plant calmodulin-binding protein with a kinesin heavy chain motor domain. Reddy, A.S., Safadi, F., Narasimhulu, S.B., Golovkin, M., Hu, X. J. Biol. Chem. (1996) [Pubmed]
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