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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RDR2  -  RNA-dependent RNA polymerase 2

Arabidopsis thaliana

Synonyms: SILENCING MOVEMENT DEFICIENT 1, SMD1, T22B4.110, T22B4_110
 
 
 
 
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High impact information on RDR2

  • Other classes of small RNAs were found to be RDR2-independent, particularly those derived from long inverted repeats and a subset of tandem repeats [1].
  • The Arabidopsis genome contains a highly complex and abundant population of small RNAs, and many of the endogenous siRNAs are dependent on RNA-Dependent RNA Polymerase 2 (RDR2) for their biogenesis [1].
  • The small RNA populations in other Arabidopsis small RNA biogenesis mutants were also examined; a dcl2/3/4 triple mutant showed a similar pattern to rdr2, whereas dcl1-7 and rdr6 showed reductions in miRNAs and ta-siRNAs consistent with their activities in the biogenesis of these types of small RNAs [1].
  • Small RNA libraries were constructed from wild-type Arabidopsis (Arabidopsis thaliana) and mutant plants (rdr2 and dcl3) that were genetically enriched for miRNAs, and a computational procedure was developed to identify candidate miRNAs [2].

References

  1. MicroRNAs and other small RNAs enriched in the Arabidopsis RNA-dependent RNA polymerase-2 mutant. Lu, C., Kulkarni, K., Souret, F.F., Muthuvalliappan, R., Tej, S.S., Poethig, R.S., Henderson, I.R., Jacobsen, S.E., Wang, W., Green, P.J., Meyers, B.C. Genome Res. (2006) [Pubmed]
  2. Expression of Arabidopsis MIRNA genes. Xie, Z., Allen, E., Fahlgren, N., Calamar, A., Givan, S.A., Carrington, J.C. Plant Physiol. (2005) [Pubmed]
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