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Gene Review

MYB18  -  transcription factor LAF1

Arabidopsis thaliana

Synonyms: AtMYB18, LAF1, LONG AFTER FAR-RED LIGHT 1, M7J2.70, M7J2_70, ...
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High impact information on AtMYB18

  • Gene expression studies showed that laf1 has reduced responsiveness to continuous far-red light but retains wild-type responses to other light wavelengths [1].
  • As far-red light is only perceived by phyA, our results suggest that LAF1 is specifically involved in phyA signal transduction [1].
  • Here, we describe a new Arabidopsis mutant, laf1 (long after far-red light 1) that has an elongated hypocotyl specifically under far-red light [1].
  • Further analyses revealed that laf1 is affected in a subset of phyA-dependent responses and the phenotype is more severe at low far-red fluence rates [1].
  • Here we show that COP1 functions as an E3 ligase ubiquitinating both itself and the myb transcription activator LAF1, which is required for complete phyA responses [2].

Regulatory relationships of AtMYB18


  1. LAF1, a MYB transcription activator for phytochrome A signaling. Ballesteros, M.L., Bolle, C., Lois, L.M., Moore, J.M., Vielle-Calzada, J.P., Grossniklaus, U., Chua, N.H. Genes Dev. (2001) [Pubmed]
  2. LAF1 ubiquitination by COP1 controls photomorphogenesis and is stimulated by SPA1. Seo, H.S., Yang, J.Y., Ishikawa, M., Bolle, C., Ballesteros, M.L., Chua, N.H. Nature (2003) [Pubmed]
  3. Independent and interdependent functions of LAF1 and HFR1 in phytochrome A signaling. Jang, I.C., Yang, S.W., Yang, J.Y., Chua, N.H. Genes Dev. (2007) [Pubmed]
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