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Gene Review:

TT7 - Flavonoid 3'-monooxygenase

Arabidopsis thaliana

Synonyms: CYP75B1, CYTOCHROME P450 75B1, D501, F13G24.190, F13G24_190, ...

Schoenbohm, C. et al., Ryan, K.G. et al., Shih, C.H. et al., Toda, K. et al.

Ryan, Swinny, Winefield, Markham,

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High impact information on TT7

A conserved amino acid sequence of F3'H proteins, GGEK, was found in the deduced polypeptide [1].
Three unique sorghum flavonoid 3'-hydroxylase (F3'H) cDNAs (SbF3'H1, SbF3'H2 and SbF3'H3) were discovered through bioinformatics analysis [2].
The availability of the AtF3'H gene and promoter sequence will allow us to study the coregulation of a complete set of flavonol and anthocyanidin biosynthesis genes in A. thaliana, and makes in vitro synthesis of hydroxylated flavonoids more feasible [3].
These results suggest that flavonols protect Arabidopsis plants from UVB damage, and indicate that the flavonoid 3'-hydroxylase (F3'H) enzyme, which converts dihydrokaempferol to dihydroquercetin, may play a crucial role [4].

References

A single-base deletion in soybean flavonoid 3'-hydroxylase gene is associated with gray pubescence color. Toda, K., Yang, D., Yamanaka, N., Watanabe, S., Harada, K., Takahashi, R. Plant Mol. Biol. (2002) [Pubmed]
Differential Expression of Two Flavonoid 3'-Hydroxylase cDNAs Involved in Biosynthesis of Anthocyanin Pigments and 3-Deoxyanthocyanidin Phytoalexins in Sorghum. Shih, C.H., Chu, I.K., Yip, W.K., Lo, C. Plant Cell Physiol. (2006) [Pubmed]
Identification of the Arabidopsis thaliana flavonoid 3'-hydroxylase gene and functional expression of the encoded P450 enzyme. Schoenbohm, C., Martens, S., Eder, C., Forkmann, G., Weisshaar, B. Biol. Chem. (2000) [Pubmed]
Flavonoids and UV photoprotection in Arabidopsis mutants. Ryan, K.G., Swinny, E.E., Winefield, C., Markham, K.R. Z. Naturforsch., C, J. Biosci. (2001) [Pubmed]

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