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Cyp1b1  -  cytochrome P450, family 1, subfamily b,...

Rattus norvegicus

Synonyms: CYPIB1, Cytochrome P450 1B1, Cytochrome P450RAP
 
 
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Disease relevance of Cyp1b1

  • We sought to determine whether two common functional polymorphisms in Cytochrome P450 1B1, V432L (m1), and A453S (m2) are related to breast cancer risk [1].
 

High impact information on Cyp1b1

  • The deduced amino acid sequence (543 residues) matched completely with five peptides cleaved from P450RAP [2].
  • DEX inhibition of TCDD-induced CYP1B1 protein needed more extensive preincubation (>6 hr) [3].
  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induced the 5.2-kilobase CYP1B1 mRNA in RMF (12-fold) and REF (14-fold) after a 6-hr treatment, with comparable increases in the microsomal protein [3].
  • Maximum EROD activity and Cyp1a1 mRNA levels were observed after approximately 12 h, whereas Cyp1a2 and Cyp1b1 mRNA levels peaked after 48 h [4].
  • PMSG induced PAH metabolism 2- to 5-fold in ovarian microsomes and also increased the P450RAP immunoblot [5].
 

Biological context of Cyp1b1

 

Anatomical context of Cyp1b1

 

Associations of Cyp1b1 with chemical compounds

  • Beta-naphthoflavone induced the expression of Cyp1a1 and Cyp1b1 transcripts, two well-characterized AHR-inducible genes that code for hydroxylases that metabolize estradiol to catecholestrogens [8].
  • Anti-P450RAP immunoblots a protein present in ovarian and testicular microsomes that is the same size as P450RAP and which coelutes with the P450 fraction during chromatography on an immobilized artificial membrane column made with phosphatidylcholine [5].
 

Analytical, diagnostic and therapeutic context of Cyp1b1

References

  1. Association of CYP1B1 polymorphisms and breast cancer risk. De Vivo, I., Hankinson, S.E., Li, L., Colditz, G.A., Hunter, D.J. Cancer Epidemiol. Biomarkers Prev. (2002) [Pubmed]
  2. Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP1B1. Demonstration of a unique tissue-specific pattern of hormonal and aryl hydrocarbon receptor-linked regulation. Bhattacharyya, K.K., Brake, P.B., Eltom, S.E., Otto, S.A., Jefcoate, C.R. J. Biol. Chem. (1995) [Pubmed]
  3. Aryl hydrocarbon receptor regulation of cytochrome P4501B1 in rat mammary fibroblasts: evidence for transcriptional repression by glucocorticoids. Brake, P.B., Zhang, L., Jefcoate, C.R. Mol. Pharmacol. (1998) [Pubmed]
  4. Indolo[3,2-b]carbazole inhibits gap junctional intercellular communication in rat primary hepatocytes and acts as a potential tumor promoter. Herrmann, S., Seidelin, M., Bisgaard, H.C., Vang, O. Carcinogenesis (2002) [Pubmed]
  5. Polycyclic aromatic hydrocarbon metabolism in rat adrenal, ovary, and testis microsomes is catalyzed by the same novel cytochrome P450 (P450RAP). Otto, S., Bhattacharyya, K.K., Jefcoate, C.R. Endocrinology (1992) [Pubmed]
  6. Effects of dietary soy and estrous cycle on adrenal cytochrome p450 1B1 expression and DMBA metabolism in adrenal glands and livers in female Sprague-Dawley rats. Fu, X., Blaydes, B.S., Weis, C.C., Latendresse, J.R., Muskhelishvili, L., Sutter, T.R., Delclos, K.B. Chem. Biol. Interact. (2003) [Pubmed]
  7. Cytochrome P450 1B1 mRNA in the human central nervous system. Rieder, C.R., Ramsden, D.B., Williams, A.C. MP, Mol. Pathol. (1998) [Pubmed]
  8. An aryl hydrocarbon receptor agonist amplifies the mitogenic actions of estradiol in granulosa cells: evidence of involvement of the cognate receptors. Bussmann, U.A., Bussmann, L.E., Barañao, J.L. Biol. Reprod. (2006) [Pubmed]
 
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