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Gene Review:

TIC40 - protein TIC 40

Arabidopsis thaliana

Synonyms: ATTIC40, MTG13.14, MTG13_14, PDE120, pigment defective embryo, ...

Ko, K. et al., Hörmann, F. et al., Kovacheva, S. et al., Chou, M.L. et al.

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Disease relevance of PDE120

Membrane proteins, Tic110 and Tic40, and a stromal chaperone, Hsp93, have been proposed to function together within the Tic complex [1].

High impact information on PDE120

Cross-linking experiments demonstrated that Tic40 was part of the translocon complex and functioned at the same stage of import as Tic110 and Hsp93, a member of the Hsp100 family of molecular chaperones [2].
This study was thus designed to combine plant-based experiments and yeast mitochondrion-based approaches for unveiling clues related to how the Tic40 components may behave during the protein translocation process [3].
Evidence that the plastid translocon Tic40 components possess modulating capabilities [3].

Other interactions of PDE120

In vivo studies on the roles of Tic110, Tic40 and Hsp93 during chloroplast protein import [1].

Analytical, diagnostic and therapeutic context of PDE120

Co-immunoprecipitation experiments using either Tic32 or Tic110 antisera indicated a tight association between these polypeptides as well as with other Tic subunits, e.g. Tic40, Tic22, or Tic62, whereas the outer envelope protein Toc75 was not found in this complex [4].

References

In vivo studies on the roles of Tic110, Tic40 and Hsp93 during chloroplast protein import. Kovacheva, S., Bédard, J., Patel, R., Dudley, P., Twell, D., Ríos, G., Koncz, C., Jarvis, P. Plant J. (2005) [Pubmed]
Tic40, a membrane-anchored co-chaperone homolog in the chloroplast protein translocon. Chou, M.L., Fitzpatrick, L.M., Tu, S.L., Budziszewski, G., Potter-Lewis, S., Akita, M., Levin, J.Z., Keegstra, K., Li, H.M. EMBO J. (2003) [Pubmed]
Evidence that the plastid translocon Tic40 components possess modulating capabilities. Ko, K., Taylor, D., Argenton, P., Innes, J., Pedram, B., Seibert, F., Granell, A., Ko, Z. J. Biol. Chem. (2005) [Pubmed]
Tic32, an essential component in chloroplast biogenesis. Hörmann, F., Küchler, M., Sveshnikov, D., Oppermann, U., Li, Y., Soll, J. J. Biol. Chem. (2004) [Pubmed]

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