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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Tics

 
 
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Disease relevance of Tics

 

Psychiatry related information on Tics

 

High impact information on Tics

  • Tics following methylphenidate administration. A report of 20 cases [10].
  • In this report, we examine the in vivo function of a major Tic component, Tic110 [11].
  • BACKGROUND: This study examined changes in attention-deficit hyperactivity (ADHD) behaviors and motor and vocal tics during long-term treatment with methylphenidate [12].
  • Clinician-rated measures of motor tic severity, the degree to which the tics are "noticeable to others," motor tic counts from videotaped interviews, and parent-rated measures of impulsivity and hyperactivity were the most responsive to clonidine treatment [13].
  • Gilles de la Tourette syndrome (GTS) is a potentially debilitating neuropsychiatric disorder defined by the presence of both vocal and motor tics [14].
 

Chemical compound and disease context of Tics

  • Tic severity decreased by 31% in the guanfacine group, compared to 0% in the placebo group [15].
  • While neuroleptics, such as haloperidol, are most effective for treatment of the motor and vocal tics of TS, these medications have many side effects [16].
  • The replacement of Phe in both pY + 1 and pY + 3 by Tic (1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) was also not tolerated due to steric hindrance [17].
  • Patients were rated for tic severity by the Yale Global Tic Severity Scale (YGTSS) before treatment and after 1 month of treatment with risperidone [18].
  • Substitution of d-Arg in position 2 with Tic and masking of the lysine amine side chain by Z protection and of the C-terminal carboxylic function instead of the amide function transform a potent and selective mu agonist into a potent and selective delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH [19].
 

Biological context of Tics

 

Anatomical context of Tics

  • Sulpiride in the perifornical lateral hypothalamus (pfLH) (4, 8 and 16 micrograms/0.5 microliter) increased intracranial temperature (Tic) [23].
  • We then investigated the correlation between the severity of tics in children with TD assessed with the Yale Global Tic Severity Scale (YGTSS) and the specific/non-specific DAT binding ratio of the basal ganglia [24].
 

Gene context of Tics

  • For the subgrouped analysis, no results were significant after correction for multiple testing, although homozygosity of DRD2/A2A2 in subjects displaying vocal or motor tics approached significance compared to controls (Fisher exact test, P = 0.008) [25].
  • Membrane proteins, Tic110 and Tic40, and a stromal chaperone, Hsp93, have been proposed to function together within the Tic complex [26].
  • In Arabidopsis, single genes, atTIC110 and atTIC40, encode the Tic proteins, and two homologous genes, atHSP93-V and atHSP93-III, encode Hsp93 [26].
  • Gilles de la Tourette syndrome (GTS) is a sporadic or inherited complex neuropsychiatric disorder characterized by involuntary motor and vocal tics [27].
  • Co-immunoprecipitation experiments using either Tic32 or Tic110 antisera indicated a tight association between these polypeptides as well as with other Tic subunits, e.g. Tic40, Tic22, or Tic62, whereas the outer envelope protein Toc75 was not found in this complex [28].

References

  1. Leber's "plus": neurological abnormalities in patients with Leber's hereditary optic neuropathy. Nikoskelainen, E.K., Marttila, R.J., Huoponen, K., Juvonen, V., Lamminen, T., Sonninen, P., Savontaus, M.L. J. Neurol. Neurosurg. Psychiatr. (1995) [Pubmed]
  2. Asperger's syndrome, X-linked mental retardation (MRX23), and chronic vocal tic disorder. Searcy, E., Burd, L., Kerbeshian, J., Stenehjem, A., Franceschini, L.A. J. Child Neurol. (2000) [Pubmed]
  3. Dyskinesias and associated psychiatric disorders following streptococcal infections. Dale, R.C., Heyman, I., Surtees, R.A., Church, A.J., Giovannoni, G., Goodman, R., Neville, B.G. Arch. Dis. Child. (2004) [Pubmed]
  4. Familial hypodigoxinemic membrane Na(+)-K(+) ATPase upregulatory syndrome - relation between digoxin status and cerebral dominance. Kumar, A.R., Kurup, P.A. Neurology India. (2002) [Pubmed]
  5. Linkage studies on Gilles de la Tourette syndrome: what is the strategy of choice? Heutink, P., van de Wetering, B.J., Pakstis, A.J., Kurlan, R., Sandor, P., Oostra, B.A., Sandkuijl, L.A. Am. J. Hum. Genet. (1995) [Pubmed]
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  7. Hereditary agoraphobia and obsessive-compulsive behaviour in relatives of patients with Gilles de la Tourette's syndrome. Comings, D.E., Comings, B.G. The British journal of psychiatry : the journal of mental science. (1987) [Pubmed]
  8. Desipramine treatment of children with attention-deficit hyperactivity disorder and tic disorder or Tourette's syndrome. Spencer, T., Biederman, J., Kerman, K., Steingard, R., Wilens, T. Journal of the American Academy of Child and Adolescent Psychiatry. (1993) [Pubmed]
  9. Comparative study of the behavioral and neuropsychologic characteristics of tic disorder with or without attention-deficit hyperactivity disorder (ADHD). Shin, M.S., Chung, S.J., Hong, K.E. J. Child Neurol. (2001) [Pubmed]
  10. Tics following methylphenidate administration. A report of 20 cases. Denckla, M.B., Bemporad, J.R., MacKay, M.C. JAMA (1976) [Pubmed]
  11. Arabidopsis tic110 is essential for the assembly and function of the protein import machinery of plastids. Inaba, T., Alvarez-Huerta, M., Li, M., Bauer, J., Ewers, C., Kessler, F., Schnell, D.J. Plant Cell (2005) [Pubmed]
  12. Long-term methylphenidate therapy in children with comorbid attention-deficit hyperactivity disorder and chronic multiple tic disorder. Gadow, K.D., Sverd, J., Sprafkin, J., Nolan, E.E., Grossman, S. Arch. Gen. Psychiatry (1999) [Pubmed]
  13. Clonidine treatment of Gilles de la Tourette's syndrome. Leckman, J.F., Hardin, M.T., Riddle, M.A., Stevenson, J., Ort, S.I., Cohen, D.J. Arch. Gen. Psychiatry (1991) [Pubmed]
  14. Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotype. State, M.W., Greally, J.M., Cuker, A., Bowers, P.N., Henegariu, O., Morgan, T.M., Gunel, M., DiLuna, M., King, R.A., Nelson, C., Donovan, A., Anderson, G.M., Leckman, J.F., Hawkins, T., Pauls, D.L., Lifton, R.P., Ward, D.C. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  15. A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder. Scahill, L., Chappell, P.B., Kim, Y.S., Schultz, R.T., Katsovich, L., Shepherd, E., Arnsten, A.F., Cohen, D.J., Leckman, J.F. The American journal of psychiatry. (2001) [Pubmed]
  16. Nicotine for the treatment of Tourette's syndrome. Sanberg, P.R., Silver, A.A., Shytle, R.D., Philipp, M.K., Cahill, D.W., Fogelson, H.M., McConville, B.J. Pharmacol. Ther. (1997) [Pubmed]
  17. Design and biological evaluation of linear and cyclic phosphopeptide ligands of the N-terminal SH2 domain of protein tyrosine phosphatase SHP-1. Imhof, D., Wieligmann, K., Hampel, K., Nothmann, D., Zoda, M.S., Schmidt-Arras, D., Zacharias, M., Böhmer, F.D., Reissmann, S. J. Med. Chem. (2005) [Pubmed]
  18. Risperidone as a treatment for Tourette's syndrome. Bruun, R.D., Budman, C.L. The Journal of clinical psychiatry. (1996) [Pubmed]
  19. From the potent and selective mu opioid receptor agonist H-Dmt-d-Arg-Phe-Lys-NH(2) to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH. Balboni, G., Cocco, M.T., Salvadori, S., Romagnoli, R., Sasaki, Y., Okada, Y., Bryant, S.D., Jinsmaa, Y., Lazarus, L.H. J. Med. Chem. (2005) [Pubmed]
  20. A small family of LLS1-related non-heme oxygenases in plants with an origin amongst oxygenic photosynthesizers. Gray, J., Wardzala, E., Yang, M., Reinbothe, S., Haller, S., Pauli, F. Plant Mol. Biol. (2004) [Pubmed]
  21. Synthesis and biological activity of [Tic5] didemnin B. Pfizenmayer, A.J., Vera, M.D., Ding, X., Xiao, D., Chen, W.C., Joullié, M.M. Bioorg. Med. Chem. Lett. (1998) [Pubmed]
  22. Comparative study on amino acid sequences of Kunitz-type soybean trypsin inhibitors, Tia, Tib, and Tic. Kim, S.H., Hara, S., Hase, S., Ikenaka, T., Toda, H., Kitamura, K., Kaizuma, N. J. Biochem. (1985) [Pubmed]
  23. Sulpiride increases and dopamine decreases intracranial temperature in rats when injected in the lateral hypothalamus: an animal model for the neuroleptic malignant syndrome? Parada, M.A., de Parada, M.P., Rada, P., Hernandez, L. Brain Res. (1995) [Pubmed]
  24. Dopamine transporter density of the basal ganglia assessed with [123I]IPT SPECT in drug-naive children with Tourette's disorder. Cheon, K.A., Ryu, Y.H., Namkoong, K., Kim, C.H., Kim, J.J., Lee, J.D. Psychiatry research. (2004) [Pubmed]
  25. DRD2, DRD3 and 5HT2A receptor genes polymorphisms in obsessive-compulsive disorder. Nicolini, H., Cruz, C., Camarena, B., Orozco, B., Kennedy, J.L., King, N., Weissbecker, K., de la Fuente, J.R., Sidenberg, D. Mol. Psychiatry (1996) [Pubmed]
  26. In vivo studies on the roles of Tic110, Tic40 and Hsp93 during chloroplast protein import. Kovacheva, S., Bédard, J., Patel, R., Dudley, P., Twell, D., Ríos, G., Koncz, C., Jarvis, P. Plant J. (2005) [Pubmed]
  27. CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorder. Verkerk, A.J., Mathews, C.A., Joosse, M., Eussen, B.H., Heutink, P., Oostra, B.A. Genomics (2003) [Pubmed]
  28. Tic32, an essential component in chloroplast biogenesis. Hörmann, F., Küchler, M., Sveshnikov, D., Oppermann, U., Li, Y., Soll, J. J. Biol. Chem. (2004) [Pubmed]
 
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