Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

TIC110 - protein TIC110

Arabidopsis thaliana

Synonyms: ARABIDOPSIS THALIANA TRANSLOCON AT THE INNER ENVELOPE MEMBRANE OF CHLOROPLASTS 110, ATTIC110, translocon at the inner envelope membrane of chloroplasts 110

Kovacheva, S. et al., Hörmann, F. et al., Chou, M.L. et al., Teng, Y.S. et al., Inaba, T. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ATTIC110/TIC110

Membrane proteins, Tic110 and Tic40, and a stromal chaperone, Hsp93, have been proposed to function together within the Tic complex [1].

High impact information on ATTIC110/TIC110

Cross-linking experiments demonstrated that Tic40 was part of the translocon complex and functioned at the same stage of import as Tic110 and Hsp93, a member of the Hsp100 family of molecular chaperones [2].
Expression levels of CIA5 were comparable to those of major translocon components, such as At Tic110 and At Toc75, except during germination, at which stage At Tic20 was expressed at its highest level [3].
In this report, we examine the in vivo function of a major Tic component, Tic110 [4].
Arabidopsis tic110 is essential for the assembly and function of the protein import machinery of plastids [4].
Tic32 can be purified from solubilized inner envelope membranes by chromatography on Tic110 containing affinity matrix [5].

Biological context of ATTIC110/TIC110

Homozygous tic110 embryos exhibited retarded growth, developmental arrest at the globular stage and a 'raspberry-like' embryo-proper phenotype [1].
In the homozygous state, the tic110 mutation caused embryo lethality, implying an essential role for atTic110 during plastid biogenesis [1].

Other interactions of ATTIC110/TIC110

In vivo studies on the roles of Tic110, Tic40 and Hsp93 during chloroplast protein import [1].

Analytical, diagnostic and therapeutic context of ATTIC110/TIC110

Co-immunoprecipitation experiments using either Tic32 or Tic110 antisera indicated a tight association between these polypeptides as well as with other Tic subunits, e.g. Tic40, Tic22, or Tic62, whereas the outer envelope protein Toc75 was not found in this complex [5].

References

In vivo studies on the roles of Tic110, Tic40 and Hsp93 during chloroplast protein import. Kovacheva, S., Bédard, J., Patel, R., Dudley, P., Twell, D., Ríos, G., Koncz, C., Jarvis, P. Plant J. (2005) [Pubmed]
Tic40, a membrane-anchored co-chaperone homolog in the chloroplast protein translocon. Chou, M.L., Fitzpatrick, L.M., Tu, S.L., Budziszewski, G., Potter-Lewis, S., Akita, M., Levin, J.Z., Keegstra, K., Li, H.M. EMBO J. (2003) [Pubmed]
Tic21 Is an Essential Translocon Component for Protein Translocation across the Chloroplast Inner Envelope Membrane. Teng, Y.S., Su, Y.S., Chen, L.J., Lee, Y.J., Hwang, I., Li, H.M. Plant Cell (2006) [Pubmed]
Arabidopsis tic110 is essential for the assembly and function of the protein import machinery of plastids. Inaba, T., Alvarez-Huerta, M., Li, M., Bauer, J., Ewers, C., Kessler, F., Schnell, D.J. Plant Cell (2005) [Pubmed]
Tic32, an essential component in chloroplast biogenesis. Hörmann, F., Küchler, M., Sveshnikov, D., Oppermann, U., Li, Y., Soll, J. J. Biol. Chem. (2004) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.