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Gene Review

HCF136  -  photosystem II stability/assembly factor...

Arabidopsis thaliana

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High impact information on HCF136

  • Immunoblot analysis of fractionated chloroplasts showed that the HCF136 protein is a lumenal protein, found only in stromal thylakoid lamellae [1].
  • We conclude that HCF136 encodes a stability and/or assembly factor of PSII which dates back to the cyanobacterial-like endosymbiont that led to the plastids of the present photosynthetic eukaryotes [1].
  • We demonstrate by in vivo radiolabeling of hcf136 that biogenesis of the reaction center (RC) of PSII is blocked [2].
  • However, twin-arginine motifs are absent from the presequences of Hcf136 proteins encoded by plastid or cyanobacterial genomes, strongly implying translocation by another pathway (presumably Sec) [3].

Biological context of HCF136

  • We suggest that the Hcf136 protein was transferred to the Tat pathway when the gene became incorporated into the nuclear genome, possibly due to the tighter folding associated with the more involved, post-translational targeting pathway [3].

Analytical, diagnostic and therapeutic context of HCF136


  1. A nuclear-encoded protein of prokaryotic origin is essential for the stability of photosystem II in Arabidopsis thaliana. Meurer, J., Plücken, H., Kowallik, K.V., Westhoff, P. EMBO J. (1998) [Pubmed]
  2. The HCF136 protein is essential for assembly of the photosystem II reaction center in Arabidopsis thaliana. Plücken, H., Müller, B., Grohmann, D., Westhoff, P., Eichacker, L.A. FEBS Lett. (2002) [Pubmed]
  3. Different lumen-targeting pathways for nuclear-encoded versus cyanobacterial/plastid-encoded Hcf136 proteins. Hynds, P.J., Plücken, H., Westhoff, P., Robinson, C. FEBS Lett. (2000) [Pubmed]
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