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GFI1B  -  growth factor independent 1B transcription...

Homo sapiens

Synonyms: Growth factor independent protein 1B, Potential regulator of CDKN1A translocated in CML, Zinc finger protein Gfi-1b
 
 
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High impact information on GFI1B

  • The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases [1].
  • Growth factor-independent 1B (GFI1B) is a transcription factor essential for the development and differentiation of erythroid and megakaryocytic lineages [2].
  • Silencing GFI1B by transfection with small interfering RNA (siRNA) markedly reduced the proliferation rate in the leukaemic cell lines HEL, K562 and NB4 (P < 0.01) [2].
  • GFI1B expression was increased at least threefold in patients with erythroleukaemia (P < 0.01 compared with controls) and megakaryocytic leukaemia (P < 0.05) as well as in their corresponding leukaemic cell lines HEL, K562, CMK and M-07e [2].
  • Concomitantly, we observed a two- to threefold increase in the apoptosis rate in these cells after transfection with siRNA towards GFI1B [2].
 

Biological context of GFI1B

  • GFI1 is upregulated in the earliest thymocyte precursors, while GFI1B expression is restricted to T lymphopoiesis stages coincident with activation [3].
 

Anatomical context of GFI1B

  • Transgenic expression of GFI1 potentiates T-cell activation, while forced GFI1B expression decreases activation [3].
  • Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells [3].

References

  1. The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases. Rödel, B., Wagner, T., Zörnig, M., Niessing, J., Möröy, T. Genomics (1998) [Pubmed]
  2. Growth factor-independent 1B gene (GFI1B) is overexpressed in erythropoietic and megakaryocytic malignancies and increases their proliferation rate. Elmaagacli, A.H., Koldehoff, M., Zakrzewski, J.L., Steckel, N.K., Ottinger, H., Beelen, D.W. Br. J. Haematol. (2007) [Pubmed]
  3. Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells. Doan, L.L., Porter, S.D., Duan, Z., Flubacher, M.M., Montoya, D., Tsichlis, P.N., Horwitz, M., Gilks, C.B., Grimes, H.L. Nucleic Acids Res. (2004) [Pubmed]
 
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