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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RAT5  -  histone H2A 1

Arabidopsis thaliana

Synonyms: ATHTA1, HTA1, MRB17.14, MRB17_14, RESISTANT TO AGROBACTERIUM TRANSFORMATION 5
 
 
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Disease relevance of RAT5

 

High impact information on RAT5

  • Transient and stable beta-glucuronidase expression data and assessment of the amount of T-DNA integrated into the genomes of wild-type and rat5 Arabidopsis plants indicated that the rat5 mutant is deficient in T-DNA integration [1].
  • We characterized an Arabidopsis mutant generated by T-DNA insertional mutagenesis, rat5, that is resistant to Agrobacterium root transformation. rat5 contains two copies of T-DNA integrated as a tandem direct repeat into the 3' untranslated region of a histone H2A gene, upstream of the polyadenylation signal sequence [1].
  • We have previously shown that the Arabidopsis thaliana gene H2A-1 (RAT5), which encodes histone H2A-1, is involved in T-DNA integration into the plant genome [2].

References

  1. An Arabidopsis histone H2A mutant is deficient in Agrobacterium T-DNA integration. Mysore, K.S., Nam, J., Gelvin, S.B. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. Expression of the Arabidopsis histone H2A-1 gene correlates with susceptibility to Agrobacterium transformation. Yi, H., Mysore, K.S., Gelvin, S.B. Plant J. (2002) [Pubmed]
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