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MeSH Review

Mutagenesis, Insertional

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Analytical, diagnostic and therapeutic context of Mutagenesis, Insertional


  1. Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Ott, M.G., Schmidt, M., Schwarzwaelder, K., Stein, S., Siler, U., Koehl, U., Glimm, H., Kühlcke, K., Schilz, A., Kunkel, H., Naundorf, S., Brinkmann, A., Deichmann, A., Fischer, M., Ball, C., Pilz, I., Dunbar, C., Du, Y., Jenkins, N.A., Copeland, N.G., Lüthi, U., Hassan, M., Thrasher, A.J., Hoelzer, D., von Kalle, C., Seger, R., Grez, M. Nat. Med. (2006) [Pubmed]
  2. Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis. Girard, L., Hanna, Z., Beaulieu, N., Hoemann, C.D., Simard, C., Kozak, C.A., Jolicoeur, P. Genes Dev. (1996) [Pubmed]
  3. Retroviruses and insertional mutagenesis in mice: proviral integration at the Mov 34 locus leads to early embryonic death. Soriano, P., Gridley, T., Jaenisch, R. Genes Dev. (1987) [Pubmed]
  4. Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands. Jhappan, C., Gallahan, D., Stahle, C., Chu, E., Smith, G.H., Merlino, G., Callahan, R. Genes Dev. (1992) [Pubmed]
  5. Codon insertion mutants of the adenovirus terminal protein. Freimuth, P.I., Ginsberg, H.S. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  6. Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice. Lund, A.H., Turner, G., Trubetskoy, A., Verhoeven, E., Wientjens, E., Hulsman, D., Russell, R., DePinho, R.A., Lenz, J., van Lohuizen, M. Nat. Genet. (2002) [Pubmed]
  7. High frequency retrotransposition in cultured mammalian cells. Moran, J.V., Holmes, S.E., Naas, T.P., DeBerardinis, R.J., Boeke, J.D., Kazazian, H.H. Cell (1996) [Pubmed]
  8. Embryonic lethal mutation in mouse collagen I gene causes rupture of blood vessels and is associated with erythropoietic and mesenchymal cell death. Löhler, J., Timpl, R., Jaenisch, R. Cell (1984) [Pubmed]
  9. Evidence from cassette mutagenesis for a structure-function motif in a protein of unknown structure. Clarke, N.D., Lien, D.C., Schimmel, P. Science (1988) [Pubmed]
  10. The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages. Saleque, S., Cameron, S., Orkin, S.H. Genes Dev. (2002) [Pubmed]
  11. Radiation resistance of human melanoma analysed by retroviral insertional mutagenesis reveals a possible role for dopachrome tautomerase. Pak, B.J., Lee, J., Thai, B.L., Fuchs, S.Y., Shaked, Y., Ronai, Z., Kerbel, R.S., Ben-David, Y. Oncogene (2004) [Pubmed]
  12. High-throughput selection of retrovirus producer cell lines leads to markedly improved efficiency of germ line-transmissible insertions in zebra fish. Chen, W., Burgess, S., Golling, G., Amsterdam, A., Hopkins, N. J. Virol. (2002) [Pubmed]
  13. Mechanistic insights provided by deletion of a flexible loop at the active site of ribulose-1,5-bisphosphate carboxylase/oxygenase. Larson, E.M., Larimer, F.W., Hartman, F.C. Biochemistry (1995) [Pubmed]
  14. Folding and stability of a tryptophan-containing mutant of ubiquitin. Khorasanizadeh, S., Peters, I.D., Butt, T.R., Roder, H. Biochemistry (1993) [Pubmed]
  15. Characterization of mechanisms of quinolone resistance in Pseudomonas aeruginosa strains isolated in vitro and in vivo during experimental endocarditis. Chamberland, S., Bayer, A.S., Schollaardt, T., Wong, S.A., Bryan, L.E. Antimicrob. Agents Chemother. (1989) [Pubmed]
  16. Introduction of site-specific mutations into the genome of influenza virus. Enami, M., Luytjes, W., Krystal, M., Palese, P. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  17. Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis. Hwang, H.C., Martins, C.P., Bronkhorst, Y., Randel, E., Berns, A., Fero, M., Clurman, B.E. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  18. Insertional mutagenesis of Drosophila heterochromatin with single P elements. Zhang, P., Spradling, A.C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  19. Molecular cloning and characterization of the yeast gene for squalene synthetase. Jennings, S.M., Tsay, Y.H., Fisch, T.M., Robinson, G.W. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  20. Substitution of the seat-belt region of the thyroid-stimulating hormone (TSH) beta-subunit with the corresponding regions of choriogonadotropin or follitropin confers luteotropic but not follitropic activity to chimeric TSH. Grossmann, M., Szkudlinski, M.W., Wong, R., Dias, J.A., Ji, T.H., Weintraub, B.D. J. Biol. Chem. (1997) [Pubmed]
  21. Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas ligand interactions. Davidson, W.F., Giese, T., Fredrickson, T.N. J. Exp. Med. (1998) [Pubmed]
  22. Spontaneous germ line virus infection and retroviral insertional mutagenesis in eighteen transgenic Srev lines of mice. Spence, S.E., Gilbert, D.J., Swing, D.A., Copeland, N.G., Jenkins, N.A. Mol. Cell. Biol. (1989) [Pubmed]
  23. Interaction of Wnt-1 proteins with the binding protein BiP. Kitajewski, J., Mason, J.O., Varmus, H.E. Mol. Cell. Biol. (1992) [Pubmed]
  24. Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma. Wotton, S., Stewart, M., Blyth, K., Vaillant, F., Kilbey, A., Neil, J.C., Cameron, E.R. Cancer Res. (2002) [Pubmed]
  25. The Chlamydomonas PF6 locus encodes a large alanine/proline-rich polypeptide that is required for assembly of a central pair projection and regulates flagellar motility. Rupp, G., O'Toole, E., Porter, M.E. Mol. Biol. Cell (2001) [Pubmed]
  26. Retroviral insertional mutagenesis identifies a small protein required for synthesis of diphthamide, the target of bacterial ADP-ribosylating toxins. Liu, S., Leppla, S.H. Mol. Cell (2003) [Pubmed]
  27. A gene homologous to chloroplast carbonic anhydrase (icfA) is essential to photosynthetic carbon dioxide fixation by Synechococcus PCC7942. Fukuzawa, H., Suzuki, E., Komukai, Y., Miyachi, S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  28. Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin. Klimpel, K.R., Molloy, S.S., Thomas, G., Leppla, S.H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  29. Retroviral insertional mutagenesis as a strategy for the identification of genes associated with cis-diamminedichloroplatinum(II) resistance. Lu, S.J., Man, S., Bani, M.R., Adachi, D., Hawley, R.G., Kerbel, R.S., Ben-David, Y. Cancer Res. (1995) [Pubmed]
  30. Role of conserved and nonconserved residues in the Ca(2+)-dependent carbohydrate-recognition domain of a rat mannose-binding protein. Analysis by random cassette mutagenesis. Quesenberry, M.S., Drickamer, K. J. Biol. Chem. (1992) [Pubmed]
  31. Regulation of the resident chromosomal copy of c-myc by c-Myb is involved in myeloid leukemogenesis. Schmidt, M., Nazarov, V., Stevens, L., Watson, R., Wolff, L. Mol. Cell. Biol. (2000) [Pubmed]
  32. RAD4 gene of Saccharomyces cerevisiae: molecular cloning and partial characterization of a gene that is inactivated in Escherichia coli. Fleer, R., Nicolet, C.M., Pure, G.A., Friedberg, E.C. Mol. Cell. Biol. (1987) [Pubmed]
  33. Multiple nucleosome positioning sites regulate the CTCF-mediated insulator function of the H19 imprinting control region. Kanduri, M., Kanduri, C., Mariano, P., Vostrov, A.A., Quitschke, W., Lobanenkov, V., Ohlsson, R. Mol. Cell. Biol. (2002) [Pubmed]
  34. Importance of Gly-13 for the coenzyme binding of human UDP-glucose dehydrogenase. Huh, J.W., Yoon, H.Y., Lee, H.J., Choi, W.B., Yang, S.J., Cho, S.W. J. Biol. Chem. (2004) [Pubmed]
  35. Retroviral insertional activation of the EVI1 oncogene does not prevent G-CSF-induced maturation of the murine pluripotent myeloid cell line 32Dcl3. Khanna-Gupta, A., Lopingco, M.C., Savinelli, T., Zibello, T., Berliner, N., Perkins, A.S. Oncogene (1996) [Pubmed]
  36. Mutational analysis of the DNA-binding domain of yeast heat shock transcription factor. Hubl, S.T., Owens, J.C., Nelson, H.C. Nat. Struct. Biol. (1994) [Pubmed]
  37. Proviral activation of the c-myb proto-oncogene is detectable in preleukemic mice infected neonatally with Moloney murine leukemia virus but not in resulting end stage T lymphomas. Belli, B., Wolff, L., Nazarov, V., Fan, H. J. Virol. (1995) [Pubmed]
  38. Biosynthesis of butirosin in Bacillus circulans NRRL B3312: identification by sequence analysis and insertional mutagenesis of the butB gene involved in antibiotic production. Aubert-Pivert, E., Davies, J. Gene (1994) [Pubmed]
  39. Histidine 454 plays an important role in polymerization of human glutamate dehydrogenase. Lee, E.Y., Huh, J.W., Yang, S.J., Choi, S.Y., Cho, S.W., Choi, H.J. FEBS Lett. (2003) [Pubmed]
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