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Gene Review


Arabidopsis thaliana

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High impact information on VIN3

  • In this pathway, prolonged cold relieves AGL19 from PcG repression by a mechanism that requires VIN3 but not VRN2 [1].
  • We show in planta that VRN2 and VIN3 are part of a large protein complex that can include the PcG proteins FERTILIZATION INDEPENDENT ENDOSPERM, CURLY LEAF, and SWINGER [2].
  • VIN3 is involved in initiating the modification of FLC chromatin structure [3].

Biological context of VIN3


Associations of VIN3 with chemical compounds

  • Our results suggest that during the prolonged cold, VRN5 and VIN3 form a heterodimer necessary for establishing the vernalization-induced chromatin modifications, histone deacetylation, and H3 lysine 27 trimethylation required for the epigenetic silencing of FLC [5].


  1. Polycomb-group proteins repress the floral activator AGL19 in the FLC-independent vernalization pathway. Schönrock, N., Bouveret, R., Leroy, O., Borghi, L., Köhler, C., Gruissem, W., Hennig, L. Genes Dev. (2006) [Pubmed]
  2. The Arabidopsis thaliana vernalization response requires a polycomb-like protein complex that also includes VERNALIZATION INSENSITIVE 3. Wood, C.C., Robertson, M., Tanner, G., Peacock, W.J., Dennis, E.S., Helliwell, C.A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Vernalization and epigenetics: how plants remember winter. Sung, S., Amasino, R.M. Curr. Opin. Plant Biol. (2004) [Pubmed]
  4. The downregulation of FLOWERING LOCUS C (FLC) expression in plants with low levels of DNA methylation and by vernalization occurs by distinct mechanisms. Jean Finnegan, E., Kovac, K.A., Jaligot, E., Sheldon, C.C., James Peacock, W., Dennis, E.S. Plant J. (2005) [Pubmed]
  5. The PHD Finger Protein VRN5 Functions in the Epigenetic Silencing of Arabidopsis FLC. Greb, T., Mylne, J.S., Crevillen, P., Geraldo, N., An, H., Gendall, A.R., Dean, C. Curr. Biol. (2007) [Pubmed]
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