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Gene Review

TRPT1  -  tRNA phosphotransferase 1

Homo sapiens

Synonyms: MGC11134, tRNA 2'-phosphotransferase 1
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High impact information on TRPT1

  • The TRPT1 gene is located at human chromosome 11q13 and encodes a polypeptide of 253 amino acids [1].
  • BLAST searches with its amino acid sequence revealed the ubiquitous occurrence of TRPT1 homologs and their functional relationships with the presence of the DUF60/KptA domain [1].
  • The results indicated that the breakpoint is located between POLD1 and TRPT at the boundary between chromosome bands 19q13.3 and 19q13.4 [2].

Analytical, diagnostic and therapeutic context of TRPT1

  • After a mean interval of 3 mo from the time of Tinit, all patients were clinically re-evaluated; those with an abnormal Tinit underwent a repeat SPECT (Trpt) as well [3].


  1. A human homolog of the yeast gene encoding tRNA 2'-phosphotransferase: cloning, characterization and complementation analysis. Hu, Q.D., Lu, H., Huo, K., Ying, K., Li, J., Xie, Y., Mao, Y., Li, Y.Y. Cell. Mol. Life Sci. (2003) [Pubmed]
  2. FISH analyses of a newly established thyroid tumor cell line showing a t(1;19)(p35 or p36.1;q13) reveal that the breakpoint lies between 19q13.3-13.4 and 19q13.4. Belge, G., Garcia, E., de Jong, P., Bartnitzke, S., Bullerdiek, J. Cytogenet. Cell Genet. (1995) [Pubmed]
  3. Prospective evaluation of technetium-99m-HMPAO SPECT in mild and moderate traumatic brain injury. Jacobs, A., Put, E., Ingels, M., Bossuyt, A. J. Nucl. Med. (1994) [Pubmed]
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