The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

POLD1  -  polymerase (DNA directed), delta 1,...

Homo sapiens

Synonyms: CDC2, CRCS10, DNA polymerase delta catalytic subunit, DNA polymerase subunit delta p125, MDPL, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of POLD1


High impact information on POLD1


Biological context of POLD1


Other interactions of POLD1

  • Thus, it was indicated that mutations in the MSH6 gene, and not in the POLD1 gene, are primarily responsible for the elevated mutation rates in DLD-1 cells [1].
  • Most of transcripts involved in DNA repair were not detected but repression of POLD1 in the adult group and induction of XRCC5 and LIG4 were observed after UVA irradiation, as a function of age [8].
  • Structure of the gene for the catalytic subunit of human DNA polymerase delta (POLD1) [9].


  1. Effect of exogenous MSH6 and POLD1 expression on the mutation rate of the HPRT locus in a human colon cancer cell line with mutator phenotype, DLD-1. Yabuta, T., Shinmura, K., Yamane, A., Yamaguchi, S., Takenoshita, S., Yokota, J. Int. J. Oncol. (2004) [Pubmed]
  2. Characterization of the human DNA polymerase delta catalytic subunit expressed by a recombinant baculovirus. Suzuki, S., Suzuki, M., Yoshida, S. Nagoya journal of medical science. (2000) [Pubmed]
  3. Total-genome analysis of BRCA1/2-related invasive carcinomas of the breast identifies tumor stroma as potential landscaper for neoplastic initiation. Weber, F., Shen, L., Fukino, K., Patocs, A., Mutter, G.L., Caldes, T., Eng, C. Am. J. Hum. Genet. (2006) [Pubmed]
  4. Transcriptional regulation of the human DNA polymerase delta catalytic subunit gene POLD1 by p53 tumor suppressor and Sp1. Li, B., Lee, M.Y. J. Biol. Chem. (2001) [Pubmed]
  5. The human POLD1 gene. Identification of an upstream activator sequence, activation by Sp1 and Sp3, and cell cycle regulation. Zhao, L., Chang, L.S. J. Biol. Chem. (1997) [Pubmed]
  6. FISH analyses of a newly established thyroid tumor cell line showing a t(1;19)(p35 or p36.1;q13) reveal that the breakpoint lies between 19q13.3-13.4 and 19q13.4. Belge, G., Garcia, E., de Jong, P., Bartnitzke, S., Bullerdiek, J. Cytogenet. Cell Genet. (1995) [Pubmed]
  7. Breakpoints of 19q13 translocations of benign thyroid tumors map within a 400 kilobase region. Belge, G., Garcia, E., Rippe, V., Fusco, A., Bartnitzke, S., Bullerdiek, J. Genes Chromosomes Cancer (1997) [Pubmed]
  8. Ageing effects on the expression of cell defence genes after UVA irradiation in human male cutaneous fibroblasts using cDNA arrays. Hazane, F., Valenti, K., Sauvaigo, S., Peinnequin, A., Mouret, C., Favier, A., Beani, J.C. J. Photochem. Photobiol. B, Biol. (2005) [Pubmed]
  9. Structure of the gene for the catalytic subunit of human DNA polymerase delta (POLD1). Chang, L.S., Zhao, L., Zhu, L., Chen, M.L., Lee, M.Y. Genomics (1995) [Pubmed]
WikiGenes - Universities