Disease relevance of TGD1

• Presumed bacterial orthologs of TGD1 and TGD2 in Gram-negative bacteria are typically organized in transcriptional units, suggesting their involvement in a common biological process [1].

High impact information on TGD1

• Mutation of the TGD1 chloroplast envelope protein affects phosphatidate metabolism in Arabidopsis [2].
• As even partial disruption of TGD1 function has drastic consequences on central lipid metabolism, the tgd1 mutant provides a tool to explore regulatory mechanisms governing lipid homeostasis and lipid trafficking in plants [2].
• Mutations in a permease-like protein, TRIGALACTOSYLDIACYLGLYCEROL1 (TGD1), in Arabidopsis thaliana caused the accumulation of triacylglycerols, oligogalactolipids, and PA [2].
• The TGD1 protein was localized to the inner chloroplast envelope and appears to be a component of a lipid transporter [2].
• The TGD1 protein is a permease-like component of an ABC transporter located in the chloroplast inner envelope membrane [1].

Biological context of TGD1

• To the extent tested, tgd2 showed a complex lipid phenotype identical to the previously described tgd1 mutant [1].

Other interactions of TGD1

• In in vitro assays, DGD2 was capable of galactosylating DGDG, resulting in the synthesis of an oligogalactolipid tentatively identified as trigalactosyldiacylglycerol [3].

References