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Gene Review:

NADK2 - NAD kinase 2

Arabidopsis thaliana

Synonyms: ATNADK2, F8K7.5, F8K7_5, NAD KINASE 2

Chai, M.F. et al., Turner, W.L. et al.

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Disease relevance of NADK2

The nadk2 plants also displayed hypersensitivity to environmental stresses provoking oxidative stress, such as UVB, drought, heat shock and salinity [1].

High impact information on NADK2

Expressed as recombinant proteins in bacteria, both NADK1 and NADK2 were catalytically active, thereby confirming their identity as NADKs [2].
Parallel to the reduced chlorophyll content, the expression levels of two POR genes, encoding key enzymes in chlorophyll synthesis, were down regulated in the nadk2 plants [1].

Biological context of NADK2

Although the predicted catalytic regions for NADK1 and NADK2 show sequence similarity to NADKs from other organisms, NADK2 possesses a large N-terminal extension that appears to be unique to plants [2].

Other interactions of NADK2

Recently, two distinct NADK isoforms (NADK1 and NADK2) have been identified in Arabidopsis [1].

References

NADK2, an Arabidopsis chloroplastic NAD kinase, plays a vital role in both chlorophyll synthesis and chloroplast protection. Chai, M.F., Chen, Q.J., An, R., Chen, Y.M., Chen, J., Wang, X.C. Plant Mol. Biol. (2005) [Pubmed]
Cloning and characterization of two NAD kinases from Arabidopsis. identification of a calmodulin binding isoform. Turner, W.L., Waller, J.C., Vanderbeld, B., Snedden, W.A. Plant Physiol. (2004) [Pubmed]

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