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Gene Review

PIP5K1A  -  phosphatidylinositol-4-phosphate 5-kinase,...

Homo sapiens

Synonyms: 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha, PIP5K1-alpha, PIP5KIalpha, Phosphatidylinositol 4-phosphate 5-kinase type I alpha, Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha, ...
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High impact information on PIP5K1A

  • When expression of PIP5KIalpha was reduced, expression of both PIP5KIbeta and PIP5KIgamma increased and PIP2 levels did not change [1].
  • Protection by the wild-type PIP5KIalpha was accompanied by decreases in the generation of activated caspases and of caspase 3-cleaved PARP [2].
  • These results show that PIP2 is a direct regulator of apical and effector caspases in the death receptor and mitochondrial pathways, and that PIP5KIalpha inactivation contributes to the progression of apoptosis [2].
  • Overexpression of phosphatidylinositol phosphate 5-kinase alpha (PIP5KIalpha), which synthesizes PIP2, suppressed apoptosis, whereas a kinase-deficient mutant did not [2].
  • Here we show that expression of DGKzeta significantly enhances PIP5KIalpha activity in thrombin-stimulated HEK293 cells, and DGK activity is required for this stimulation [3].

Biological context of PIP5K1A


Anatomical context of PIP5K1A

  • Supporting that PIP5KIalpha regulation occurs at the sites of actin polymerization, we found that PIP2 also accumulated in the actin-rich regions of lamellipodia [3].

Co-localisations of PIP5K1A

  • We also observed that DGKzeta co-immunoprecipitated and co-localized with PIP5KIalpha, suggesting that they reside in a regulated signaling complex [3].

Other interactions of PIP5K1A

  • Combined, these data support a novel function for DGKzeta: by generating PA, it stimulates PIP5KIalpha activity to increase local PIP2, which regulates actin polymerization [3].


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