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Gene Review

PIP5K1B  -  phosphatidylinositol-4-phosphate 5-kinase,...

Homo sapiens

Synonyms: MSS4, PIP5K1-beta, PIP5KIbeta, Phosphatidylinositol 4-phosphate 5-kinase type I beta, Phosphatidylinositol 4-phosphate 5-kinase type-1 beta, ...
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Disease relevance of PIP5K1B


High impact information on PIP5K1B


Biological context of PIP5K1B


Anatomical context of PIP5K1B


Associations of PIP5K1B with chemical compounds


Other interactions of PIP5K1B

  • We now report the exon-intron structure of STM7.I and primer sequences designed to facilitate full characterization, including details relating to a novel exon (STM7; exon 17) derived from the 3'-UTR of the PRKACG gene [4].
  • PIP2 levels and internalization of transferrin receptors dropped 50% in these cells; thus, PIP5KIgamma could not compensate for loss of PIP5KIbeta [2].

Analytical, diagnostic and therapeutic context of PIP5K1B

  • Purification, crystallization and preliminary X-ray crystallographic analysis of mammalian MSS4-Rab8 GTPase protein complex [6].


  1. The Friedreich's ataxia gene encodes a novel phosphatidylinositol-4- phosphate 5-kinase. Carvajal, J.J., Pook, M.A., dos Santos, M., Doudney, K., Hillermann, R., Minogue, S., Williamson, R., Hsuan, J.J., Chamberlain, S. Nat. Genet. (1996) [Pubmed]
  2. Phosphatidylinositol phosphate 5-kinase Ibeta recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis. Padrón, D., Wang, Y.J., Yamamoto, M., Yin, H., Roth, M.G. J. Cell Biol. (2003) [Pubmed]
  3. Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family. Loijens, J.C., Anderson, R.A. J. Biol. Chem. (1996) [Pubmed]
  4. Exon-intron structure of a 2.7-kb transcript of the STM7 gene with phosphatidylinositol-4-phosphate 5-kinase activity. Pook, M.A., Carvajal, J.J., Doudney, K., Hillermann, R., Chamberlain, S. Genomics (1997) [Pubmed]
  5. Hypertonic Stress Increases Phosphatidylinositol 4,5-Bisphosphate Levels by Activating PIP5KIbeta. Yamamoto, M., Chen, M.Z., Wang, Y.J., Sun, H.Q., Wei, Y., Martinez, M., Yin, H.L. J. Biol. Chem. (2006) [Pubmed]
  6. Purification, crystallization and preliminary X-ray crystallographic analysis of mammalian MSS4-Rab8 GTPase protein complex. Itzen, A., Bleimling, N., Ignatev, A., Pylypenko, O., Rak, A. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2006) [Pubmed]
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