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Gene Review:

Hao2 - hydroxyacid oxidase 2 (long chain)

Rattus norvegicus

Synonyms: (S)-2-hydroxy-acid oxidase, peroxisomal, HAOX2, Hao3, Haox2, Hydroxyacid oxidase 2, ...

Lee, S.J. et al., Belmouden, A. et al., Diêp Lê, K.H. et al., Ozasa, H. et al.

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High impact information on Hao2

Amino acid sequence of long chain alpha-hydroxy acid oxidase from rat kidney, a member of the family of FMN-dependent alpha-hydroxy acid-oxidizing enzymes [1].
Molecular cloning and nucleotide sequence of cDNA encoding rat kidney long-chain L-2-hydroxy acid oxidase. Expression of the catalytically active recombinant protein as a chimaera [2].
Seven out of 37 differentially expressed genes were mapped to congenic regions carrying BP QTLs, but only one of these genes, L-2 hydroxy acid oxidase (Hao2), showed the congenic strain-specific pattern of differential kidney gene expression predicted by its chromosomal location [3].
This data suggests that Hao2 should be examined as a candidate gene for the rat chromosome 2 (RNO2) BP QTL [3].
Methylguanidine synthase from rat kidney is identical to long-chain L-2-hydroxy acid oxidase [4].

References

Amino acid sequence of long chain alpha-hydroxy acid oxidase from rat kidney, a member of the family of FMN-dependent alpha-hydroxy acid-oxidizing enzymes. Diêp Lê, K.H., Lederer, F. J. Biol. Chem. (1991) [Pubmed]
Molecular cloning and nucleotide sequence of cDNA encoding rat kidney long-chain L-2-hydroxy acid oxidase. Expression of the catalytically active recombinant protein as a chimaera. Belmouden, A., Lê, K.H., Lederer, F., Garchon, H.J. Eur. J. Biochem. (1993) [Pubmed]
Use of a panel of congenic strains to evaluate differentially expressed genes as candidate genes for blood pressure quantitative trait loci. Lee, S.J., Liu, J., Qi, N., Guarnera, R.A., Lee, S.Y., Cicila, G.T. Hypertens. Res. (2003) [Pubmed]
Methylguanidine synthase from rat kidney is identical to long-chain L-2-hydroxy acid oxidase. Ozasa, H., Horikawa, S., Ota, K. Nephron (1994) [Pubmed]

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AT3G14130	Arabidopsis thaliana
AT3G14150	Arabidopsis thaliana
HAO2	Bos taurus
HAO2	Canis lupus familiaris
hao2	Danio rerio
HAO2	Gallus gallus
HAO2	Homo sapiens
KLLA0D02640g	Kluyveromyces lactis NRRL Y-1140
HAO2	Macaca mulatta
MGG_01723	Magnaporthe oryzae 70-15
Hao2	Mus musculus
NCU08272	Neurospora crassa OR74A
Os07g0616500	Oryza sativa Japonica Group
HAO2	Pan troglodytes
CYB2	Saccharomyces cerevisiae S288c
hao2	Xenopus (Silurana) tropicalis

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