Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Chn2 - chimerin 2

Rattus norvegicus

Synonyms: Arhgap3, Bch, Beta-chimaerin, Beta-chimerin, Rho GTPase-activating protein 3

Leung, T. et al., Bustamante, J.C. et al.

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High impact information on Chn2

Germ cell beta-chimaerin, a new GTPase-activating protein for p21rac, is specifically expressed during the acrosomal assembly stage in rat testis [1].
In situ hybridization and cell fractionation analyses show beta-chimaerin mRNA expression to be stage-specific, paralleling acrosomal assembly at the late stage of spermatogenesis [1].
The transport of L-Leu in the testis was also inhibited by L-Phe or D-Phe, D-Leu, and by the synthetic amino acid Bch, the characteristic marker for the L system, but was only slightly reduced if the perfusate was free of sodium, as is expected for the L system [2].

References

Germ cell beta-chimaerin, a new GTPase-activating protein for p21rac, is specifically expressed during the acrosomal assembly stage in rat testis. Leung, T., How, B.E., Manser, E., Lim, L. J. Biol. Chem. (1993) [Pubmed]
The uptake of amino acids, in particular leucine, by isolated perfused testes of rats. Bustamante, J.C., Setchell, B.P. J. Androl. (2000) [Pubmed]

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